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Fifty-nine Staphylococcus aureus isolates and 1 isolate of Staphylococcus intermedius were typed by investigators at eight institutions by using either antibiograms, bacteriophage typing, biotyping, immunoblotting, insertion sequence typing with IS257/431, multilocus enzyme electrophoresis, restriction analysis of plasmid DNA, pulsed-field or field(More)
Clinical study results for neurokinin (NK) receptor antagonists in the treatment of depression have been mixed, with Phase III studies failing to fulfill the early promise demonstrated in Phase II studies. Casopitant, a selective NK1 antagonist that achieves nearly complete receptor occupancy was studied in 2 randomized, placebo-controlled, double-blind,(More)
PURPOSE Internal fixation has become a well-established alternative to casting for acute scaphoid fractures. Screw design has evolved, and several different types of screws of varying sizes are now available. The purpose of this study was to establish morphometric data for the human scaphoid, document variation in scaphoid dimensions between genders, and to(More)
Bacterial endocarditis is a serious medical complication of heroin addiction and should be suspected in any addict with a fever and positive blood cultures. However, gram-negative bacteria, and particularly Pseudomonas aeruginosa, are uncommon causes of bacterial endocarditis and their presence in a blood culture may be dismissed as a contaminant or as(More)
Rabbits with left-sided endocarditis due to Pseudomonas aeruginosa were treated with a high dose (7.5 mg/kg) of gentamicin for six days, a low dose (5 mg/kg) of gentamicin for six days or two weeks, carbenicillin (400 mg/kg) for six days or two weeks, or a combination of the lower dose of gentamicin and carbenicillin (400 mg/kg) for six days or two weeks.(More)
Two strains of Staphylococcus aureus expressing borderline or low-level methicillin resistance by one or more in vitro test methods were examined for resistance in vivo and for biochemical and genetic markers of methicillin resistance. In vivo, nafcillin was equally effective against experimental aortic valve endocarditis in rabbits, regardless of whether(More)
Intravenous miconazole, an investigational, broad-spectrum, antifungal imidazole drug, was clinically effective when used for the first time in a patient with life-threatening sporotrichosis. Miconazole was used after drug resistance and treatment failure occurred in a patient with extensive, cavitary, pulmonary infection with Sporotrichum schenckii. He had(More)
Rabbits with sterile, right ventricular cardiac vegetationss were challenged with Staphylococcus aureus and serum-susceptible or -resistant isolates of Pseudomonas aeruginosa. None of the rabbits challenged with serum-susceptible P. aeruginosa died or had greater than 10(2) colony-forming units (cfu)/g cultured from vegetations two weeks later. In contrast,(More)
STUDY OBJECTIVES Investigate the hypnotic effects of repeated doses of neurokinin-1 receptor antagonist, vestipitant, in primary insomnia. DESIGN Randomized, double-blind, placebo-controlled 28-day parallel-group study. SETTING Eleven sleep centers in Germany. PATIENTS One hundred sixty-one patients with primary insomnia. INTERVENTIONS Patients(More)
Full, persistent blockade of central neurokinin-1 (NK1) receptors may be a potential antidepressant mechanism. The selective NK1 antagonist orvepitant (GW823296) was used to test this hypothesis. A preliminary positron emission tomography study in eight male volunteers drove dose selection for two randomized six week studies in patients with major(More)