Grady S Meneilly

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OBJECTIVE The purpose of this study was to determine the relationships between plasma adiponectin and leptin levels, total and central obesity, and glucose utilization across the adult age span. RESEARCH DESIGN AND METHODS We studied 148 women aged 18-81 years with a BMI range of 17.2-44.3 kg/m(2). Total percent body fat was determined by dual-energy(More)
We have examined the requirement for Ca2+ in the signaling and trafficking pathways involved in insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Chelation of intracellular Ca2+, using 1,2-bis (o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra (acetoxy- methyl) ester (BAPTA-AM), resulted in >95% inhibition of insulin-stimulated glucose uptake.(More)
We have examined the requirement for Ca in the signaling and trafficking pathways involved in insulinstimulated glucose uptake in 3T3-L1 adipocytes. Chelation of intracellular Ca, using 1,2-bis (o-aminophenoxy)ethane-N,N,N*,N*-tetraacetic acid tetra (acetoxymethyl) ester (BAPTA-AM), resulted in >95% inhibition of insulin-stimulated glucose uptake. The(More)
Diabetes is common in the elderly. Recently, investigators have begun to systematically study the pathogenesis of this illness in the aged. These studies suggest that although there are many similarities between diabetes in middle-aged and elderly subjects, there are several ways in which diabetes in the elderly is unique. These differences may have(More)
AIM To evaluate the pharmacokinetic and pharmacodynamic properties of insulin aspart in elderly patients with diabetes. METHODS Studies were conducted in elderly patients with diabetes (n = 19, M/F 10/9, age 72 +/- 1 years, BMI 27 +/- 1 kg/m(2), HbA(1c) 6.4 +/- 0.1%, diabetes duration < 5 years). Nine patients were treated with metformin, and ten with(More)
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