Gracinda de Sousa

Learn More
The relationship between memory complaints and objective memory performance remains poorly understood, particularly in young and middle aged people. We studied the relationship between reports of memory complaints and objective memory performance, and the possibility of differentiating good and poor reporters across the lifespan based on concordance between(More)
The current multi-layered interventional approaches to blood safety have dramatically reduced the risk of viral contamination of blood components. Nowadays most of the residual transfusion transmitted infections (TTI) occur as the result of the interval between the time the donor is infected and the moment at which tests are capable of detecting the agent,(More)
Platelets are known to undergo shape change, activation, a release reaction and apoptosis/necrosis during processing and storage, all of which are collectively known as the platelet storage lesion. Any additional processing may have some deleterious impact on platelet activability and functional integrity, which need to be investigated. This preliminary(More)
The current status of potential adverse reactions associated with the use of apheresis technology is reviewed, focussing on three main areas: adverse events related to component collection, progenitor cells collection and therapeutic apheresis. Based on available information it is believed that apheresis technologies are safe and increasingly used in(More)
The screening laboratory has a critical role in the post-transfusion safety. The success of its targets and efficiency depends on the management system used. Even though the European Union directive 2002/98/EC requires a quality management system in blood establishments, its requirements for screening laboratories are generic. Complementary approaches are(More)
Exposure of phosphatidyl-serine on blood cell membrane surface and microvesiculation as the hallmarks of apoptosis/necrosis were investigated. The effect of leukofiltration on the retention/generation of microvesicules, leukocyte subsets and major biological response modifiers were evaluated in a like study. It is concluded that apoptotic cells potentially(More)
Two experts from Octapharma and from Cerus addressed, in very concise ways, the concerns about non-viral inactivated FFP and how they managed to obtain highest standard of safety margin for pathogen reduction treatment [PRT] of plasma. The session was moderated by Portuguese Institute of Blood and Transplantation (PIBT) consultant advisor [Jerard(More)