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Basal complement activity presents a potential danger for "self" cells that are tightly protected by complement regulators including CD59. Mice express two Cd59 genes (mCd59a and mCd59b); mCd59b has approximately a 6-fold higher specific activity than mCd59a. Consistently, mCd59b knockout mice present a strong phenotype characterized by hemolytic anemia(More)
Thyroid hormones play major roles in the regulation of a wide range of metabolic and physiologic processes, but the genes and environmental factors that affect normal, quantitative variation in thyroid hormone concentrations are largely unknown. Using quantitative genetic methods, we evaluated the effects of genes and environmental factors on thyroid(More)
BACKGROUND Intestinal retransplantation (Re-ITx) has historically been associated with high morbidity and mortality. METHODS The outcomes of all children receiving Re-ITx between 1990 and 2007 at our center were reviewed. RESULTS One hundred seventy-two children received primary intestinal grafts. Fourteen children (8.1%) were retransplanted with 15(More)
This paper studies the trends in height-by-age across socioeconomic groups of Chilean boys aged 5-18 born between 1880 and 1997, by performing a meta-analysis of 38 studies reporting height-by-age published since 1898. We estimate the trends using quantile regressions and by analyzing detailed height data from five selected studies. Both methods yield an(More)
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