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Our results show that 2,4-dichlorophenoxyacetic acid (2,4-D) exposure through mother's milk during the period of rapid myelination (from the 15th to the 25th postnatal days) results in a myelin deficit in the pup's brain and demonstrates the vulnerability of the developing central nervous system (CNS) to 2,4-D. After 100 mg/kg 2,4-D administration to dams,(More)
In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO₃) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V₁ group) or with 7.2 mg/kg bw/day of NaVO₃ (V₂ group) for 5 consecutive days. Results show that after only 5 days of NaVO₃ exposure,(More)
The current study was performed to assess the vanadium(V)-induced developmental toxicity in sucklings of Wistar rats. Dams of treated litters were intraperitoneally injected with 3 mg NaVO(3)/kg body weight/day during 12 days starting on postnatal day (PND) 10. Surface righting reflex, negative geotaxy and hindlimb support tests were performed on pups every(More)
As vanadium was found to induce oxidative stress in the central nervous system, the morphological alterations of neurons and astroglial cells in adult rat central nervous system after vanadium exposure was studied, using histological markers of cellular injury. Animals were intraperitoneally injected with 3 mg/kg body weight of sodium metavanadate for 5(More)
The effect of sodium metavanadate (NaVO3) exposure on lipid oxidative damage in the CNS of suckling rats was studied. Using histological markers of cellular injury, we also studied the morphological alterations of neurons and astroglial cells in different regions of neonate rats CNS after NaVO3 exposure. Dams of treated litters were intraperitoneally(More)
Neonate rats were exposed to 100 mg/kg from the PND 7 to PND 25 or at 70 mg/kg from PND 12 to PND 25. Treated and control pups were subjected to several behavioral tests (righting reflex, negative geotaxy, forelimbs support and open field) during the period of treatment. At PND 25 the regional effects of 2,4-D on gangliosides composition and myelin(More)
2,4-D is a chlorophenoxyherbicide used worldwide. We have studied the morphological alterations of 5-HT neurons and glial cells in the mesencephalic nuclei of adult rats exposed to 2,4-D both perinatally (during pregnancy and lactation) and chronically (during pregnancy, lactation and after weaning) with quantitative methods. Pregnant rats were daily(More)
Comparison of serotonin-immunoreactive (SER-IR) neurons in nucleus raphe dorsalis (NRD) and median raphe nucleus (MRN) of 25-d-old rat pups exposed to 70 mg/kg/d 2,4-dichloro-phenoxyacetic acid through mothers milk and control pups was made using an immunohistochemical analysis. Significant 2,4-D-treatment-related increase in size and density of SER-IR(More)
Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22). Pups (22 days old) were anesthetized and fixed by transcardiac perfusion. Control and treated serial sections(More)
In the present work we show morphological data of the in vivo susceptibility of CNS myelin to sodium metavanadate [V(+5)] in adult rats. The possible role of vanadium in behavioral alterations and in brain lipid peroxidation was also investigated. Animals were injected intraperitoneally (i.p.) with 3 mg/kg body weight (bw) of sodium metavanadate [1.25 V/kg(More)