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Cardiovascular and Electrocardiographic Effects of the Dopamine Receptor Agonists Ropinirole, Apomorphine, and PNU-142774E in Conscious Beagle Dogs
- S. J. Humphrey, C. Turman, J. T. Curry, Gracella J Wheeler
- Chemistry, Medicine
- Journal of cardiovascular pharmacology
- 1 March 2006
It is established that in conscious dogs, the selective dopamine receptor agonist PNU-142774E has fewer cardiovascular and emetic effects than ropinirole and apomorphine and supports prior in vitro findings that ropinisrole and Apomorphine but not the PNu-14 2774E imidazoquinolin analog sumanirole reduces the delayed rectifier current in HERG transfected cells. Expand