The Open Regulatory Annotation database (ORegAnno) is a resource for curated regulatory annotation. It contains information about regulatory regions, transcription factor binding sites, RNA binding sites, regulatory variants, haplotypes, and other regulatory elements. ORegAnno differentiates itself from other regulatory resources by facilitating… (More)
BACKGROUND Previous research has found relationships between specific indoor environmental exposures and exacerbation of asthma. OBJECTIVES In this review we provide an updated summary of knowledge from the scientific literature on indoor exposures and exacerbation of asthma. METHODS Peer-reviewed articles published from 2000 to 2013 on indoor exposures… (More)
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health. Reduction in the expression of mitochondrial malonyl CoA-acyl carrier protein transacylase, a key enzyme in the pathway encoded by the nuclear Mcat gene, was achieved to varying… (More)
KRAS mutational analysis is a genetic test used in clinical practice for determining the status of the KRAS gene (wild type or mutant) in tumors from patients with metastatic colorectal cancer (CRC). Persons whose tumors are wild type may respond to therapies cetuximab (Erbitux) or panitumumab (Vectibix).
Changes in animal movement (frequency or speed of locomotion) following exposure to a toxicant are frequently considered a biomarker of contaminant exposure and are some of the most widely reported behavioral results in toxicological literature. However, the ecological consequences of such behavioral changes, such as effects on toxicant transfer in… (More)
The current system of regulating the multi-billion-dollar pharmaceutical industry via market exclusivity comes from the Drug Price Competition and Patent Term Restoration Act of 1984, also known as the Hatch-Waxman Act. The statute creates the framework for controlling the entry of generic drugs by a notification and certification system that heavily relies… (More)
Introduction Many previous studies in auditory neurophysiology have used simple tonal stimuli to understand how neurons encode sound. While these studies have shed light on many important neural characteristics, pure tones do not typically occur in our environment. Instead, we are often surrounded by multiple sound sources with complex harmonic and… (More)