Grace Ruiting Lin

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Tankyrases constitute potential drug targets for cancer and myelin-degrading diseases. We have applied a structure- and biophysics-driven fragment-based ligand design strategy to discover a novel family of potent inhibitors for human tankyrases. Biophysical screening based on a thermal shift assay identified highly efficient fragments binding in the(More)
A dc-voltage-controlled optoelectronic delay line for continuous tuning of the relative delay time of an optical pulse train generated from a gain-switched laser diode is demonstrated. A maximum tunable range delay time of 3.9 ns ( approximately 2 periods) for optical pulses at a 500-MHz repetition rate is reported, which corresponds to a phase shift of as(More)
Porcupine is a component of the Wnt pathway which regulates cell proliferation, migration, stem cell self-renewal, and differentiation. The Wnt pathway has been shown to be dysregulated in a variety of cancers. Porcupine is a membrane bound O-acyltransferase that palmitoylates Wnt. Inhibiting porcupine blocks the secretion of Wnt and effectively inhibits(More)
We report an aqueous chemical method to fabricate well-aligned ZnO/Al(2)O(3) nanocrystal (NC) core-shell nanorod arrays (NRAs). Structural characterization showed that the shell layers are composed of alpha-Al(2)O(3) nanocrystals. Photoluminescence measurements showed the enhancement of near-band-edge (NBE) emission of ZnO NRAs due to the presence of(More)
We demonstrate a delay-line-free electro-optic sampling (EOS) system by using a novel ultrafast laser with a voltage-controlled pulse-delay tuning circuit (PDTC). The digital PDTC was designed as a substitute for a conventional optomechanical delay line in the EOS system, which facilitates the theoretical phase-tuning range of 4pi. The maximum delay time,(More)
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers. Consequently porcupine inhibitors are thought to be promising oncology therapeutics. A high throughput screen against porcupine revealed several potent hits that were confirmed to be Wnt pathway(More)
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