Grace L. Raja

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To determine the maximal tolerated dose (MTD) of the combination of weekly temsirolimus and every other week vinorelbine in patients with advanced or refractory solid tumors. Patients were treated with intravenous temsirolimus on days 1, 8, 15, and 22 and intravenous vinorelbine on days 1 and 15. Cycles were repeated every 28 days. Nineteen patients were(More)
OBJECTIVES There is interest in improving the tumoricidal effects of preoperative radiotherapy for rectal carcinoma by studying new radiosensitizers. The safety and toxicity profile of these combination regimens needs rigorous clinical evaluation. The primary objective of this study was to evaluate the toxicity of combining bavituximab, an antibody that(More)
Conventional parallel cascade control structure (PCCS) does not yield satisfactory closed-loop performance for processes with large time delay. To overcome this limitation, this manuscript presents a modified Smith delay compensator based PCCS. Stable, integrating and unstable processes with dead time are considered in this work. The proposed PCCS consists(More)
This manuscript presents a modified parallel cascade control structure (PCCS) for a class of stable, unstable and integrating process models with time delay. The proposed PCCS consists of three controllers. Internal Model Control (IMC) approach is used to design the disturbance rejection controller in the secondary loop. Parameters of the(More)
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