Grace E . MacEwan

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BACKGROUND IL-6 is an inflammatory cytokine that controls effector T cell responses but the mechanisms by which it controls allogeneic immune responses and vascular rejection that leads to transplant arteriosclerosis (TA) are poorly understood. METHODS We have examined the mechanism by which IL-6 contributes to the pathogenesis of vascular rejection and(More)
OBJECTIVE Bim is a proapoptotic Bcl-2 protein known to downregulate immune responses and to also be required for antigen-induced T-cell activation. However, it is not known how the effect of Bim on these offsetting processes determines the outcome of allogeneic immune responses. We have defined the role of Bim in regulating alloantigen-driven T-cell(More)
Heart transplantation is a life-saving procedure, but its use is limited by the eventual failure of most grafts largely because of immune-mediated processes. As such, understanding the basic mechanisms by which allogeneic immune responses are regulated is essential for the development of strategies that prevent heart transplant failure. Immunologic(More)
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