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Acyl carrier proteins (ACPs) are central hubs in polyketide and fatty acid biosynthetic pathways, but the fast motions of the ACP's phosphopantetheine (Ppant) arm make its conformational dynamics… (More)
Polyketide synthases (PKSs) and fatty acid synthases (FASs) in microorganisms rely on selective and specific protein-protein interactions to build structurally complex molecules. These synthases… (More)
The successful engineering of biosynthetic pathways hinges on understanding the factors that influence acyl carrier protein (ACP) stability and function. The stability and structure of ACPs can be… (More)