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- Zsuzsanna Gáborik, Gowraganahalli Jagadeesh, Meng Zhang, András Spät, Kevin J. Catt, László Hunyady
- Endocrinology
- 2003
The pleiotropic actions of angiotensin II are mediated by the primarily G(q) protein-coupled type 1 angiotensin (AT(1)) receptor. In this study a mutational analysis of the function of the conserved… (More)
- Pitchal Balakumar, Gowraganahalli Jagadeesh
- Journal of molecular endocrinology
- 2014
The renin-angiotensin system (RAS) plays an important role in the pathophysiology of cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led to the discovery of renin… (More)
- Zsuzsanna Gáborik, Balázs Mihalik, S. K. Jayadev, Gowraganahalli Jagadeesh, Kevin J. Catt, László Hunyady
- FEBS letters
- 1998
A series of deletion mutants was created to analyze the function of the membrane-proximal region of the cytoplasmic tail of the rat type 1a (AT1a) angiotensin receptor. In transiently transfected… (More)
- Pitchal Balakumar, Gowraganahalli Jagadeesh
- Pharmacological research
- 2010
The mammalian heart during its development and in response to physiological or pathological stimuli undergoes hypertrophic enlargement, a consequence of an increase in cardiac myocyte size. Cardiac… (More)
- Pitchal Balakumar, Gowraganahalli Jagadeesh
- Cellular signalling
- 2014
Ang II, the primary effector pleiotropic hormone of the renin-angiotensin system (RAS) cascade, mediates physiological control of blood pressure and electrolyte balance through its action on vascular… (More)
- S. K. Jayadev, Roger D Smith, Gowraganahalli Jagadeesh, Albert J. Baukal, László Hunyady, Kevin J. Catt
- Endocrinology
- 1999
The nature and role of glycosylation in AT1 angiotensin receptor (AT1-R) function were investigated by expressing glycosylation-deficient influenza hemagglutinin (HA) epitope-tagged rat AT1a-Rs… (More)
- Pitchal Balakumar, Khin Maung-U, Gowraganahalli Jagadeesh
- Pharmacological research
- 2016
Noncommunicable diseases (NCDs) have become important causes of mortality on a global scale. According to the report of World Health Organization (WHO), NCDs killed 38 million people (out of 56… (More)
- Pitchal Balakumar, Gowraganahalli Jagadeesh
- Hypertension Research
- 2011
The renin–angiotensin system and Wnt/frizzled receptor signaling pathways are important in the development of essential organs, and their aberrant activation results in cardiovascular and renal… (More)
- Gowraganahalli Jagadeesh
- Indian journal of experimental biology
- 1998
The renin-angiotensin-aldosterone system (RAAS) plays an important role in both the short-term and long-term regulation of arterial blood pressure, and fluid and electrolyte balance. The RAAS is a… (More)
- Gregory V. Nikiforovich, Meng Zhang, +5 authors Kevin J. Catt
- Chemical biology & drug design
- 2006
Site-directed mutagenesis studies and independent molecular modeling studies were combined to investigate the network of inter-residue interactions within the transmembrane region of the angiotensin… (More)