Gotoku Ando

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Tinidazole was administered to healthy volunteers and serum concentrations were measured following single oral and intravenous doses and after repeated dosage at different dose levels. The elimination half-time was 12-13 h. Pharmacokinetics did not change with dose, route of administration or repeated dosage. The bioavailability of single oral doses ranged(More)
Osteoarthritis of knee joint is the disease that can be easily found at the ordinary examination. The aging and the continuous long-term stress are the most important ones among the many kind of causing factors. Most of osteoarthritis is appeared in medial femorotibial joint. The second largest number of osteoarthritis is appeared in patellofemoral joint.(More)
BACKGROUND Systemic Hypertension (SH) is the main cause of left ventricular (LV) hypertrophy in the general population, but only scanty data are available on LV geometric remodeling (LVGR) in hypertensive patients with GH deficiency (GHD). AIM We investigated hypertensive LVGR in adult-onset GHD patients, before (T0) and after 55±16 months (T1) of(More)
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