Gospodinka Radeva Prakova

Learn More
Susceptibility to silicosis and to disease severity is in part genetically determined. In this study, the role of IL-12B-3'UTR polymorphism in susceptibility and severity of silicosis and its influence on IL-12p40 and IL-12p70 serum level were investigated. The quantity of IL-12p40 and IL-12p70 was detected by enzyme-linked immunosorbent assay and the(More)
To assess the role of IL-12Bpro and GSTP1 polymorphisms on induced interleukin (IL)-12p40 production in respect to silicosis development, we examined their distribution in 63 silicosis patients and 165 healthy donors. Decreased frequencies of IL-12Bpro-2 allele (42% vs 62.5%, P = 0.0042) and genotype 22 (19% vs 40%, P = 0.02) in patients compared with(More)
The aim of the current study was to adapt a method for assessment of total antioxidant capacity of plasma by measuring the ferrous reducing activity of plasma (FRAP method), to determine factors affecting FRAP levels in patients with COPD and in control individuals, and to elucidate the possible effect of FRAP on lung function. Methods: The plasma total(More)
It has been well defined that obesity is strongly linked with several respiratory symptoms and diseases, but no convincing evidence has been provided for chronic obstructive pulmonary disease (COPD). In the current study, we aim to assess the possible prevalence of obesity in patients with COPD in a cross-sectional case-control study of individuals from the(More)
This study was carried out on 104 workers at three work operations and a control (nonproduction) area, within a methyl methacrylate (MMA)/polymethyl methacrylate (PMMA) production facility in Bulgaria. Airborne monitoring was conducted over a 10-year period for MMA and the reactant chemicals methanol and acetone cyanhydrine at the MMA operation, and MMA was(More)
The aim of the present study was to investigate the correlation between tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-12p40-containing cytokines, in silicosis patients and healthy donors exposed to silica dust, in an attempt to clarify the reason for variety of clinical outcomes between humans with similar exposure history. Serum levels of(More)
In this study, IL-6 and IL-12p40 production and cell viability of peripheral blood mononuclear cells from silicosis patients after in vitro stimulation were investigated. Furthermore, the effects of introducing acetylsalicylic acid to stimulated patients' peripheral blood mononuclear cells on cytokine production and cell viability were determined. Nine(More)
Neopterin is produced by the macrophage-monocyte cells (MMC) under the influence of interferon-γ and indirectly reflects its synthesis in the body, thus being an integral marker for the activation of the cellular immune response. The aim of this work was to investigate serum neopterin in subjects exposed to dust from synthetic abrasives. Materials and(More)
Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults. The incidence of CLL is about 3-4/100 000 inhabitants in European countries (25% of all leukemia). About 163 new patients with CLL are diagnosed in Bulgaria every year. The exact causes of the disease are unknown, such as family history is extremely rare. The aim of this work(More)
  • 1