Goro Otsuka

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Objective—The mechanisms through which transforming growth factor (TGF)-␤1 promotes intimal growth, and the pathways through which TGF-␤1 expression is regulated in the artery wall, are incompletely understood. We used a mouse model to investigate mechanisms of TGF-␤1–induced intimal growth. Methods and Results—Adenovirus-mediated overexpression of TGF-␤1(More)
OBJECT Neurofibromatosis Type 2 (NF2) is an intractable disorder predisposing to multiple, recurrent tumors of the central nervous system (CNS). To clarify the survival rate and characteristics that predict poor survival, we retrospectively reviewed clinical data in cases of NF2. METHODS From among 283 patients with neurofibromatosis who had been(More)
BACKGROUND From 2003 through to 2004, an outbreak of tuberculosis was identified at a university campus in Yokohama City, located in the southern part of the Tokyo Metropolitan Area (TMA). All Mycobacterium tuberculosis (M. tuberculosis) strains detected with regards to this outbreak turned out to be Streptomycin resistant with matched patterns of 14 IS6110(More)
8 Correction We noticed a one-digit error on the tandem repeat number at the MIRU 20 after the publication of our article [1]. This was due to a typing error. The tandem repeat number at the MIRU 20 should be 2 instead of 1. All the figures indicating the tandem repeat number at the MIRU 20, i.e. the fifth digit of the VNTR profile from the left end of the(More)
We retrospectively reviewed characteristics of patients with neurofibromatosis type 2 to identify factors predicting further growth of bilateral vestibular schwannomas. Subjects comprised 27 neurofibromatosis type 2 patients with 54 vestibular schwannomas, followed for 24-204 months (mean, 86 months). This study investigated factors predictive of vestibular(More)
A 29-year-old man suffered repeated subarachnoid hemorrhage and cerebral ischemic stroke over a period of 6 years. Cerebral angiography at each episode disclosed development of multiple de novo aneurysms at the bilateral middle cerebral arteries (MCAs), internal carotid arteries, right anterior cerebral artery, and right vertebral artery. Two of the(More)
BACKGROUND AND PURPOSE The pathogenesis and optimal treatment for arterial dissection are still unclear. We devised an experimental model of arterial dissection and observed the morphologic changes with angiography. METHODS Sixty-four experimental dissections were created in the common carotid arteries of 34 mongrel dogs. After a small incision was made(More)
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