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How transmitter receptors modulate neuronal signaling by regulating voltage-gated ion channel expression remains an open question. Here we report dendritic localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates synaptic plasticity, and its local translational regulation by fragile X mental retardation protein (FMRP) linked to fragile(More)
Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse changes in FXS. We demonstrate powerful new(More)
Voltage-gated ion channels are critical to excitation-secretion coupling in nerve terminals. We have identified two distinct populations of rat neurohypophysial (NHP) terminals distinguished by size, neuropeptide content and electrophysiological properties, including resting membrane potential, action potential (AP) properties, and K+ current and Na+(More)
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