Bradley Spencer-Dene10
Emma Nye10
Julian Downward6
Charles Swanton6
10Bradley Spencer-Dene
10Emma Nye
6Julian Downward
6Charles Swanton
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  • Ralph Fritsch, Inge de Krijger, Kornelia Fritsch, Roger George, Beth Reason, Madhu S. Kumar +3 others
  • 2013
RAS proteins are important direct activators of p110α, p110γ, and p110δ type I phosphoinositide 3-kinases (PI3Ks), interacting via an amino-terminal RAS-binding domain (RBD). Here, we investigate the regulation of the ubiquitous p110β isoform of PI3K, implicated in G-protein-coupled receptor (GPCR) signaling, PTEN-loss-driven cancers, and thrombocyte(More)
  • Surbhi Gupta, Antoine R. Ramjaun, Paula Haiko, Yihua Wang, Patricia H. Warne, Barbara Nicke +4 others
  • 2007
Ras proteins signal through direct interaction with a number of effector enzymes, including type I phosphoinositide (PI) 3-kinases. Although the ability of Ras to control PI 3-kinase has been well established in manipulated cell culture models, evidence for a role of the interaction of endogenous Ras with PI 3-kinase in normal and malignant cell growth in(More)
DNA ligase IV is the most recently identified member of a family of enzymes joining DNA strand breaks in mammalian cell nuclei [1] [2]. The enzyme occurs in a complex with the XRCC4 gene product [3], an interaction mediated via its unique carboxyl terminus [4] [5]. Cells lacking XRCC4 are hypersensitive to ionising radiation and defective in V(D)J(More)
  • Madhu S. Kumar, David C. Hancock, Miriam Molina-Arcas, Michael Steckel, Phillip East, Markus Diefenbacher +7 others
  • 2012
Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer deaths worldwide; nearly half contain mutations in the receptor tyrosine kinase/RAS pathway. Here we show that RAS-pathway mutant NSCLC cells depend on the transcription factor GATA2. Loss of GATA2 reduced the viability of NSCLC cells with RAS-pathway mutations, whereas wild-type cells(More)
MUC1 mucin is transcriptionally regulated by estrogen, progesterone, and glucocorticoids. Our objective was to determine whether androgen receptor (AR) activation regulates expression of MUC1. The following breast and prostatic cell lines were phenotyped and grouped according to AR and MUC1 protein expression: 1) AR+MUC1 + [DAR17+19 (AR transfectants of(More)
Transforming growth factor-β (TGF-β) signalling plays a key role in colorectal cancer (CRC). Bone morphogenetic protein-4 (BMP4) is a member of the TGF-β family of signal transduction molecules. To examine if germline mutation in BMP4 causes CRC we analysed 504 genetically enriched CRC cases (by virtue of early-onset disease, family history of CRC) for(More)
  • Susana Aguilar, Chris J. Scotton, Katrina McNulty, Emma Nye, Gordon Stamp, Geoff Laurent +2 others
  • 2009
Many common diseases of the gas exchange surface of the lung have no specific treatment but cause serious morbidity and mortality. Idiopathic Pulmonary Fibrosis (IPF) is characterized by alveolar epithelial cell injury, interstitial inflammation, fibroblast proliferation and collagen accumulation within the lung parenchyma. Keratinocyte Growth Factor (KGF,(More)
  • Sophie E. Acton, Aaron J. Farrugia, Jillian L. Astarita, Diego Mourão-Sá, Robert P. Jenkins, Emma Nye +10 others
  • 2014
After immunogenic challenge, infiltrating and dividing lymphocytes markedly increase lymph node cellularity, leading to organ expansion. Here we report that the physical elasticity of lymph nodes is maintained in part by podoplanin (PDPN) signalling in stromal fibroblastic reticular cells (FRCs) and its modulation by CLEC-2 expressed on dendritic cells. We(More)
  • Esther Castellano, Clare Sheridan, May Zaw Thin, Emma Nye, Bradley Spencer-Dene, Markus E. Diefenbacher +7 others
  • 2013
RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS-driven tumors. However, it is unknown whether interaction of RAS with PI3-kinase is required in established tumors. The need for RAS interaction with p110α in the maintenance of(More)
  • Stefania Segditsas, Oliver Sieber, Maesha Deheragoda, Phil East, Andrew Rowan, Rosemary Jeffery +9 others
  • 2008
In order to identify new genes with differential expression in early intestinal tumours, we performed mRNA (messenger ribonucleic acid) expression profiling of 16 human and 63 mouse adenomas. All individuals had germline APC mutations to ensure that tumorigenesis was driven by 'second hits' at APC. Using stringent filtering to identify changes consistent(More)