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The relationships between perception of verticality by different sensory modalities, lateropulsion and pushing behaviour and lesion location were investigated in 86 patients with a first stroke. Participants sat restrained in a drum-like framework facing along the axis of rotation. They gave estimates of their subjective postural vertical by signalling the(More)
The use of natalizumab for highly active relapsing-remitting multiple sclerosis (MS) is influenced by the occurrence of progressive multifocal leukoencephalopathy (PML). Through measurement of the anti-JCV antibody index, and in combination with the presence or absence of other known risk factors, it may be possible to stratify patients with MS according to(More)
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802(More)
Orientation of the body with respect to gravity is based on integration of visual, vestibular and somatosensory signals. Here, we investigated the subjective postural vertical (SPV) and visual vertical (SVV) in three patients with bilateral somatosensory deafferentation and a group of age-matched normal subjects. Our hypothesis was that the patients with(More)
After binding, central nervous system (CNS) myelin-derived axon growth inhibitory ligands, the Nogo-66 receptor (NgR), complexes with LINGO-1 and either the low-affinity neurotrophin receptor (p75(NTR)) or TROY to initiate growth cone collapse via a Rho-A inhibitory signaling pathway and/or Ca(2+)-dependent activation of epidermal growth factor receptor(More)
  • Author Contributions, D Booth, B Fontaine, C Martin, M.-B, I Kockum +73 others
  • 2016
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis and managed the project data. Abstract Using the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (p-value < 1.0 ×(More)
  • Author Contributions, D Booth, B Fontaine, C Martin, M.-B, I Kockum +73 others
  • 2013
and managed the project data. Abstract Using the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (p-value < 1.0 × 10-4). In a replication phase, we combined these data with previous genome-wide association study(More)
  • Citation Beecham, N A Patsopoulos, D K Xifara, M F Davis, A Kemppinen, C Cotsapas +79 others
  • 2013
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. and managed the project data. Abstract Using the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and(More)
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