Gordon Mazibrada

Learn More
Recurrent falls are a disabling feature of Parkinson's disease (PD). We have estimated the incidence of falling over a prospective 3 month follow-up from a large sample size, identified predictors for falling for PD patients repeated this analysis for patients without prior falls, and examined the risk of falling with increasing disease severity. We pooled(More)
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802(More)
After binding, central nervous system (CNS) myelin-derived axon growth inhibitory ligands, the Nogo-66 receptor (NgR), complexes with LINGO-1 and either the low-affinity neurotrophin receptor (p75(NTR)) or TROY to initiate growth cone collapse via a Rho-A inhibitory signaling pathway and/or Ca(2+)-dependent activation of epidermal growth factor receptor(More)
Postural instability, recurrent falls and fear of falling are common in advanced Parkinson's disease (PD). We examined the impact of fall frequency, fear of falling, balance confidence and objectively measured balance impairment (using Tinetti's Mobility Index) on health-related quality of life (HrQoL) in PD. In 74 subjects HrQoL was assessed using the(More)
To cite: Abbas A, Garg A, Jain R, et al. Pract Neurol 2016;16:326–327. IMAGE OF THE MOMENT A 23-year-old Caucasian woman presented acutely to the emergency department with mild confusion and recurring stereotyped seizures that comprised a tingling sensation in her right arm and leg, followed by a generalised tonic–clonic seizure. She had been diagnosed with(More)
Dealing with treatment-related lymphopenia is now a routine, if not a daily, issue for neurologists and/or clinical nurse specialists managing patients with multiple sclerosis (MS) on diseasemodifying therapies (DMTs). Lymphopenia is a frequent occurrence on interferon-beta, mitoxantrone, fingolimod, teriflunomide, dimethyl fumarate and alemtuzumab, which(More)
  • 1