Gordon L Todd

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BACKGROUND The C-terminal Eps15 homology domain-containing protein 1 (EHD1) is ubiquitously expressed and regulates the endocytic trafficking and recycling of membrane components and several transmembrane receptors. To elucidate the function of EHD1 in mammalian development, we generated Ehd1-/- mice using a Cre/loxP system. RESULTS Both male and female(More)
Members of the four-member C-terminal EPS15-Homology Domain-containing (EHD) protein family play crucial roles in endocytic recycling of cell surface receptors from endosomes to the plasma membrane. In this study, we show that Ehd1 gene knockout in mice on a predominantly B6 background is embryonic lethal. Ehd1-null embryos die at mid-gestation with a(More)
The relationship of subarachnoid hemorrhage and cardiac arrhythmias was studied utilizing a Sprague-Dawley rat model. A total of 30 male animals were divided into five groups and given subarachnoid injections of either blood, blood fractions, or control substances. Blood pressure, intracranial pressure, serum electrolytes, arterial blood gases, hypothalamic(More)
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