Gordon Hazen

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Due to organ scarcity and wait-list mortality, transplantation of donation after cardiac death (DCD) livers has increased. However, the group of patients benefiting from DCD liver transplantation is unknown. We studied the comparative effectiveness of DCD versus donation after brain death (DBD) liver transplantation. A Markov model was constructed to(More)
T demonstrate post hoc robustness of decision problems to parameter estimates, analysts may conduct a probabilistic sensitivity analysis, assigning distributions to uncertain parameters and computing the probability of decision change. In contrast to classical threshold proximity methods of sensitivity analysis, no appealing graphical methods are available(More)
The most common methods of sensitivity analysis (SA) in decision-analytic modeling are based either on proximity in parameter-space to decision thresholds or on the range of payoffs that accompany parameter variation. As an alternative, we propose the use of the expected value of perfect information (EVPI) as a sensitivity measure and argue from first(More)
W a decision analyst desires a sensitivity analysis on model parameters that are estimated from data, a natural approach is to vary each parameter within one or two standard errors of its estimate. This approach can be problematic if parameter estimates are correlated or if model structure does not permit obvious standard error estimates. Both of these(More)
OBJECTIVE Quality of life may represent not just quality of health but also the degree to which an individual achieves personally meaningful extrinsic goals unrelated to life duration that are not incorporated in the standard quality-adjusted life year model. The objectives of this study are to develop a typology of life goals and explore whether goal type(More)
H status is inherently a multiattribute construct. We examine multiattribute utility decompositions for the quality-adjusted life year (QALY) utility model commonly employed in medical decision and costeffectiveness analyses. We consider several independence conditions on preference, including the classical notions of preferential independence and utility(More)
Methods for evaluating health quality are central to medical decision analyses. The most important such method is the quality-adjusted life year (or QALY), in which a patient's length of life is given weight proportional to quality of health. QALYs have become ubiquitous in medical cost-effectiveness as a measure of preference for health outcomes. However,(More)
There are complex risk-benefit tradeoffs with different transplantation strategies for end-stage liver disease patients on renal support. Using a Markov discrete-time state transition model, we compared survival for this group with 3 strategies: simultaneous liver-kidney (SLK) transplantation, liver transplantation alone (LTA) followed by immediate kidney(More)
The field of solid organ transplantation has historically concentrated research efforts on basic science and translational studies. However, there has been increasing interest in health services and outcomes research. The aim was to build an effective and sustainable, inter- and transdisciplinary health services and outcomes research team (NUTORC), that(More)