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3511 Background: Radiotherapy reduces local recurrence (LR) when combined with surgery in resectable rectal cancer. The Medical Research Council CR07 trial was designed to compare two different radiotherapy policies when combined with mesorectal excision. METHODS Patients with operable non-metastatic adenocarcinoma of the rectum were randomised to either(More)
BACKGROUND PRF1 gene mutations are associated with familial haemophagocytic lymphohistiocytosis type 2 (FHL2). Genotype-phenotype analysis, previously hampered by limited numbers of patients, was for the first time performed by data pooling from five large centres worldwide. PATIENTS AND METHODS Members of the Histiocyte Society were asked to report cases(More)
Cognitive modeling typically predicts the externally observable results of tasks and psychological experiments such as participant reaction times and error rates. To understand better the neural processes associated with cognition and behavior, it is necessary to model the internal processes. In this paper, we present a method of building a cognitive model(More)
3512 Background: The MRC CR07 trial compared routine short course pre-operative radiotherapy (PRE) with selective post-operative chemo-radiation if there was involvement of the circumferential resection margin (CRM) (POST) and included a prospective pathological assessment of the quality of resection of the surgical specimen. METHODS A total of 1350(More)
The degree of cutaneous sensory deficit in the leg was assessed after removal of the long saphenous vein in 50 consecutive patients undergoing coronary artery bypass vein grafts randomly assigned subcutaneous sutures or a single layer of sutures. Removal of the vein and repair of the leg incision were done by the same team of surgeons. In group 1 (25(More)
BACKGROUND Limited data describe patient-reported outcomes (PROs) of localised oesophageal cancer treated with definitive chemoradiotherapy(CRT). The phase 2/3 SCOPE-1 trial assessed the effectiveness of CRT±cetuximab. The trial for the first time provided an opportunity to describe PROs from a multi-centre group of patients treated with CRT that are(More)
We explored the relationships between a perceptual-attention task and a word-verification task using event-related potential (ERPs) in preschool children. Adopting an embodied multiple representation perspective, we set up the relationships between online (visual attention) and offline (mental imagery) simulation in the two tasks to test key aspects of(More)
The neural correlates of visualization underlying word comprehension were examined in preschool children. On each trial, a concrete or abstract word was delivered binaurally (part 1: post-auditory visualization), followed by a four-picture array (a target plus three distractors; part 2: matching visualization). Children were to select the picture matching(More)
The aim of this study was to determine whether biochemical markers for inflammation could prove effective in identifying the most appropriate patients with suspected inflammatory bowel disease (IBD) for labelled white cell scanning. One hundred and twenty-five patients referred for 99mTc-HMPAO labelled white cell scans were investigated. The values of(More)
TPS161 Background: Plasma endothelin-1 levels are elevated in CRC patients and are prognostic for worse outcome. Endothelin-A receptor (ETAR) expression is increased in CRC samples compared with normal tissue. Antagonism of ETAR enhances cytotoxicity when combined pre-clinically with chemotherapeutics (Growcott JW, 2009. Anticancer Drugs 20: 83-88). We(More)