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PURPOSE To develop a procedure using a noninvasive technique that will allow the investigation of choroidal blood flow (ChBF) regulation in discrete regions of the cat eye. Validation of this procedure will provide a method to study intrinsic, neural, and pharmacologic factors that regulate regional ChBF. METHODS The technique to measure ChBF is based on(More)
of our community partners who assisted in the compilation of the survey instrument, the Healthy Youth Survey (HYS), which was used in this research. We also thank the many research assistants who helped in the data collection and Wenbo Zeng for assistance with data analyses. Resources in support of this project were also provided by the Centre for Youth and(More)
PURPOSE Nitric oxide (NO) has been found to be an endothelial-derived relaxing factor mediating the vasodilatation that results from the stimulation of muscarinic endothelial receptors. It also has been identified as a putative neurotransmitter of parasympathetic origin in choroidal perivascular autonomic fibers. The authors investigated a potential role of(More)
PURPOSE To investigate the contribution to the photopic negative response (PhNR) of the electroretinogram (ERG) by retinal ganglion cells (RGCs). The PhNR was assessed longitudinally following optic nerve transection (ONTx). METHODS Photopic ERGs were recorded from each eye of an anesthetized (ketamine/xylazine, 60 mg/kg and 5 mg/kg) Brown Norway rat(More)
Recent theories of drug dependence propose that the transition from occasional recreational substance use to harmful use and dependence results from the impact of disrupted midbrain dopamine signals for reinforcement learning on frontal brain areas that implement cognitive control and decision-making. We investigated this hypothesis in humans using(More)
The prevalence and correlates of symptoms of depression in a Canadian urban sample were examined. A random sample of 524 respondents completed the CES-D scale and a variety of sociodemographic questions. In this Sample, 15% of the males and 19% of the females had scores above the depression cut-point of 16 on the CES-D scale. These rates were very similar(More)