Gordana S Kartelija

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The effects of 2.7 mT and 10 mT static magnetic fields were investigated on two identified neurons with different bioelectric properties of the snail Helix pomatia. Membrane resting potential, amplitude, spiking frequency, and duration of action potential were measured. The two neurons of H. pomatia, parabolic burster Br and silent N1, showed different(More)
In addition to regular photoreceptors, some invertebrates possess simple extraocular photoreceptors. For example, the central ganglia of mollusks contain photosensitive neurons. These neurons are located on the dorsal surface of the ganglia and based on their electrophysiological properties, it has been postulated that they are the internal photoreceptors.(More)
Competitive glutamate receptor antagonists APV and CNQX were injected with kainate unilaterally into CA3 region of the rat hippocampus. They both expressed sufficient neuroprotection in the sense of decreasing superoxide production and increasing MnSOD levels, but with differential effect in mechanisms and time dynamics. Our findings suggest that NMDA and(More)
The effect of extremely low frequency magnetic fields (50 Hz, 0.5 mT) - ELF-MF, on phosphate metabolism has been studied in the isolated ganglions of the garden snail Helix pomatia, after 7 and 16 days of snail exposure to ELF-MF. The influence of ELF-MF on the level of phosphate compounds and intracellular pH was monitored by ³¹P NMR spectroscopy.(More)
In the photosensitive MB neuron in the left parietal ganglion of Helix pomatia, the onset of light prolongs significantly (by about 40%) the duration of the action potential. The broadening of the action potential after the onset of light was found to be due to its calcium component and could not be induced after blocking Ca(2+) channels by Cd(2+) and(More)
The involvement of NMDA and AMPA/kainate receptors in the induction of superoxide radical production in the rat brain was examined after injection of kainate, non-NMDA receptor agonist, kainate plus 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), selective AMPA/kainate receptor antagonist, or kainate plus 2-amino-5-phosphonopentanoic acid (APV), selective NMDA(More)
The effect of light and cyclic nucleotides (cGMP and cAMP) on a group of identified photosensitive neurons in Helix pomatia left parietal ganglion was examined. The onset of light induces in these cells a slow inward current shift associated with decrement of slope conductance. The reversal potential (Erev) of the light induced current (IL) and its changes(More)
Clinical use of chlorpromazine (CPZ), an antipsychotic drug, is limited due to its hepatotoxicity. CPZ is found to inhibit in vitro intracellular carboxylesterases (CE), such as α-naphthyl acetate esterase, naphthol AS-D chloroacetate esterase, and α-naphthyl butyrate esterase in polymorphonuclear neutrophils, hepatocytes, and neuronal brain cells from(More)
The Br neuron of the snail Helix pomatia, involved in neuronal regulation of various homeostatic and adaptive mechanisms, represents an interesting model for studying effects of temperature changes on neuronal activity of poikilotherms. The acetylcholine (ACh) induces a transient, inward dose-dependent current in the identified Br neuron. In the work(More)
The effect of ergot alkaloids, some of them from the ergosine series, was tested on the response of an identified neurone of Helix pomatia to the application of dopamine (DA) which was membrane hyperpolarization (DA-I response). To evaluate the antagonistic potency of the ergot alkaloids, the dose-response relationship of the response to DA was established(More)