Goran Ohlén

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BACKGROUND High graft strains incurred during rehabilitation after anterior cruciate ligament reconstruction may be minimized if an external compressive load is simultaneously applied to the joint during closed kinetic chain exercises. HYPOTHESES Peak anterior cruciate ligament strains will 1). increase with an increase in resistance torque during an(More)
The effects of reduced intercellular coupling in the sinus node were investigated by means of simulations. Coupling was reduced both uniformly, and by introducing localized interaction blocks. In either case, model sinus node element networks typically splitted into frequency domains. These were defined as groups of neighbour elements which all attained the(More)
In an accompanying study, it was seen that most cardiac arrhythmias that were simulated during poor intercellular coupling in the sinus node, were the same as those obtained in a two-element system in which one element suffered from a strong leakage current. This element corresponds to the sinus node periphery and is thus the one which feeds the atrium. In(More)
Tachyarrhythmias of the heart can be due to the presence of one or more spiral waves of electrical activity. Spiral waves were simulated using a previously described ionic model of cardiac action potentials in a 75 x 75 network of compartments. The compartments were connected by means of resistors and made isotropic in order to catch basic properties of(More)
A simple model for the simulation of re-entrant excitation was created. The model consists of a matrix of 15x15 compartments, where each compartment has its own action potential that depends dynamically on four ion currents (INa, ICa, Ik and Ib) having time and voltage-dependent activation and inactivation kinetics. The compartments were combined with(More)
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