Gopalan Vijaya

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INTRODUCTION AND HYPOTHESIS Overactive bladder (OAB) has a multifactorial aetiology, and for some women symptoms may be associated with chronic urothelial inflammation secondary to bacterial colonisation. One marker of such inflammation may be urinary nerve growth factor (NGF). We hypothesised that for women with OAB and urothelial inflammation, urinary NGF(More)
Biomarkers constitute any objectively measurable indicator of a biological process. The classic biomarker used in the diagnosis of overactive bladder (OAB) has been detrusor overactivity, which is assessed urodynamically. In the search for a reliable, noninvasive alternative to urodynamics, interest has focused on genetic, imaging, and urinary factors.(More)
AIMS To calculate the prevalence of pubovisceral muscle (PM) avulsion in a cohort of women presenting at a university hospital for non-urogynecological conditions. METHODS Women with or without symptoms of PFD were studied in a tertiary referral urogynecology center between February and October 2010. Women were recruited from the Department of Radiology,(More)
INTRODUCTION AND HYPOTHESIS The aim of our study was to compare air-charged and water-filled catheters simultaneously in the measurement of the intravesical, abdominal and detrusor pressure during urodynamic investigations. METHODS Consecutive women with lower urinary tract symptoms, referred for urodynamics were prospectively studied. Readings of(More)
OBJECTIVE To investigate changes in the oxygenated and deoxygenated haemoglobin (Hb) of the bladder wall during voluntary and involuntary detrusor contractions. STUDY DESIGN Women with lower urinary tract symptoms were recruited from a urodynamics clinic. Near infra-red spectroscopy, a non-invasive optical technique which monitors changes in tissue(More)
AIMS To evaluate the effect of Tolterodine on urethral and bladder afferent nerves in women with detrusor overactivity (DO) in comparison to placebo, by studying the changes in the current perception threshold (CPT). METHODS Women with overactive bladder symptoms and idiopathic DO were recruited and randomized in a double-blind manner between placebo and(More)
OBJECTIVE To study the deformation of the levator ani muscle in vivo with the use of real-time ultrasound imaging of the pelvic floor. STUDY DESIGN Thirty-two women with symptoms of pelvic floor dysfunction underwent real-time in vivo assessment of the strain of the pelvic floor during Valsalva effort. All participants underwent clinical examination,(More)
INTRODUCTION AND HYPOTHESIS The validity and reliability of measurement of urinary NGF as a diagnostic biomarker in women with lower urinary tract dysfunction (LUTD) is uncertain. We aimed to evaluate both the diagnostic and discriminant validity, and the test-retest reliability of urinary NGF measurement in women with LUTD. METHODS Urinary NGF was(More)
The purpose of the present research was to produce a quick/slow biphasic delivery system for aceclofenac. A dual component tablet made of a sustained release tabletted core and an immediate release tabletted coat was prepared by direct compression. Both the core and the coat contained a model drug aceclofenac. The sustained release effect was achieved with(More)