Gopala K. Kovvali

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Defects in DNA mismatch repair result in instability of simple repetitive DNA sequences and elevated levels of spontaneous mutability. The human G/T mismatch binding protein, GTBP/p160, has been suggested to have a role in the repair of base-base and single nucleotide insertion-deletion mismatches. Here we examine the role of the yeast GTBP homolog, MSH6,(More)
DNA mismatch repair plays a key role in the maintenance of genetic fidelity. Mutations in the human mismatch repair genes hMSH2, hMLH1, hPMS1, and hPMS2 are associated with hereditary nonpolyposis colorectal cancer. The proliferating cell nuclear antigen (PCNA) is essential for DNA replication, where it acts as a processivity factor. Here, we identify a(More)
The evidence that nuclear proteins can be degraded by cytosolic proteasomes has received considerable experimental support. However, the presence of proteasome subunits in the nucleus also suggests that protein degradation could occur within this organelle. We determined that Sts1 can target proteasomes to the nucleus and facilitate the degradation of a(More)
Simple repetitive DNA sequences are unstable in human colorectal cancers and a variety of other cancers. Mutations in the DNA mismatch repair genes MSH2, MLH1, and PMS1 result in elevated rates of spontaneous mutation and cause a marked increase in the instability of simple repeats. Compared with the wild type, a null mutation in the yeast RTH1 gene, which(More)
Address: 1Crohn's and Colitis Center of New Jersey, Department of Medicine, The University of Medicine and Dentistry of New Jersey Room 7023, 125 Paterson Street, Clinical Academic Building, New Brunswick NJ 08901, United States, USA, 2Department of Molecular Genetics, Micorbiology and Immunology/Cancer Institute of New Jersey, The University of Medicine(More)
The past three years have been satisfying publishing years for JC, given the fact that it is an online publication with processing charges paid by the authors under the open access model and there has been stiff competition from the established print journals. The quality of manuscripts published in JC is very impressive and I am confident that it will only(More)
Both developed and less developed countries are becoming increasingly urbanized. The earlier industrialized countries have developed more infrastructure to support the building of healthy housing, in neighborhoods that are strongly linked to municipal and global health initiatives, but to some degree housing and neighborhood issues vary only in degree(More)
The conference covered several contemporary topics like apoptosis, angiogenesis and several interesting and insightful talks were presented by the delegates. The keynote addresses ' Cancer predisposition', on the opening day by Dr. HT Lynch, the father of lynch syndrome, a hereditary non polyposis colorectal cancer (HNPCC) is a highlight of the symposium.(More)