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Abstract A new polyene-polyhydroxy compound, amphidinol 2 ( 2 ), was isolated as a potent hemolytic and antifungal agent from a cultured strain of dinoflagellate Amphidinium klebsii . The structure… Continue Reading
Dinoflagellates, a type of primitive unicellular algae, are a rich source of structurally and biologically intriguing natural products; e.g., okadaic acid, brevetoxins, ciguatoxins, and maitotoxin.… Continue Reading
Theopederins K (1) and L (2) have been isolated from the marine sponge Discodermia sp. collected from Honduras. 1 and 2 showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation,… Continue Reading
Discodermolide (1) and five new discodermolide analogues trivially named 2-epi-discodermolide (2), 2-des-methyldiscodermolide (3), 5-hydroxymethyldiscodermolate (4),… Continue Reading
6-Hydroxydiscodermindole (2), a new discodermindole analogue, has been isolated from the deep-water marine sponge Discodermia polydiscus. It showed marginal in vitro cytotoxicity against cultured… Continue Reading