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BACKGROUND To assess the impact of gender as an independent risk factor for early and late morbidity and mortality following coronary artery bypass surgery. METHODS Perioperative and long-term data on all 4,823 patients undergoing isolated coronary bypass operations from November 1989 to July 1998 were analyzed. Of these patients, 932 (19.3%) were(More)
BACKGROUND Preoperative renal failure increases the morbidity and mortality of coronary artery bypass graft (CABG) surgery. The results of CABG in patients with non-dialysis-dependent, mild renal insufficiency are unknown. METHODS From a population of 2978 consecutive patients undergoing isolated CABG from 1990 to 1996, 38 patients with preoperative renal(More)
BACKGROUND Sutureless aortic valve replacement (AVR) has recently been introduced as an alternative to standard AVR in elderly high-risk surgical patients. The purpose of this study was to report the early Canadian experience with sutureless AVR. METHODS A Canadian multicenter study included 215 consecutive patients from 6 centres who underwent sutureless(More)
BACKGROUND The demographics of patients undergoing coronary artery bypass grafting (CABG) have changed over time and may contribute to differing operative mortality and the combination of mortality and morbidity (M + M). In this study, the trends in results are analyzed and causes are suggested. METHODS Prospectively collected data concerning 4,839 CABG(More)
To determine whether the relative decline in cardiac myosin isoenzyme V1 with maturation continues progressively into senescence and whether thyroxine could reverse age-associated changes in the myosin isoenzyme profile and contraction, rats 2, 8, and 24 months old were treated with thyroxine, 6.4 mg/kg, for 7 days. Myosin isoenzymes, Ca2+-myosin ATPase(More)
Laser light scattered by nonstimulated rat cardiac muscle bathed in physiological saline containing a [Ca++] of 0.4-2.5 mM displays scattered-light intensity fluctuations (SLIF); the frequencies of both SLIF and resting force are Ca++ dependent. Direct inspection of these muscles by phase-contrast microscopy under incoherent illumination revealed the(More)
BACKGROUND Clinical studies of myocardial protection rarely identify differences in hard clinical outcomes after surgery, either early or late, because most trials lack sufficient statistical power to deal with low-frequency events. METHODS Prospectively collected data concerning all isolated coronary bypass operations from November 1989 to February 2000(More)