Gopal Bhaskaran

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The corpora allata (CA) of Manduca sexta larvae become incapable of synthesizing juvenile hormone (JH) early in the wandering stage of the last larval stadium. They then switch to the synthesis and release of JH acids. This change in CA activity is induced by an inhibitory factor--allatinhibin (AI)--from the brain. AI activity is present in the fifth (Vth)(More)
The inactivation of corpora allata (CA) in the last-instar larva of the tobacco hornworm Manduca sexta was studied using in vivo assay methods that test the capacity of the glands to induce an extra larval molt. Results indicate that the CA are inactivated by a two-step process. In the first step, a neurohormonal inhibition occurs by day 1 after ecdysis,(More)
lnterleukin-4 as a potent down-regulator for human alveolar macrophages capable of producing tumour necrosis factor-a and interleukin-1. ABSTRACT: The effects of recomblnant human lnterleukln-4 (IL-4) on the produc· tlon of lnterleuldn·l (ILl) and tumour necrosis factor-a (fNFa) by human alveolar macrophages (AM) and autologous peripheral blood monocytes(More)
Performance model solvers and simulation engines have been around for more than two decades. Yet, performance modeling has not received wide acceptance in the software industry, unlike pervasion of modeling and simulation tools in other industries. This paper explores underlying causes and looks at challenges that need to be overcome to increase utility of(More)
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