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  • Martin Egli, George Minasov, +8 authors M. Manoharan M. Manoharan
  • Chemistry, Medicine
  • Biochemistry
  • 2005 (First Publication: 1 June 2005)
  • The syntheses of 10 new RNA 2'-O-modifications, their incorporation into oligonucleotides, and an evaluation of their properties such as RNA affinity and nuclease resistance relevant to antisenseExpand
  • Ian R. Graham, Vanessa J. Hill, Muthiah Manoharan, Gopal B. Inamati, George Dickson
  • Biology, Medicine
  • The journal of gene medicine
  • 2004 (First Publication: 1 October 2004)
  • BACKGROUND The activity of synthetic antisense oligonucleotides (splicomers) designed to block pre-mRNA splicing at specific exons has been demonstrated in a number of model systems, includingExpand
  • Ali Sabahi, Jesse J. Guidry, Gopal B. Inamati, Muthiah Manoharan, Pernilla Wittung-Stafshede
  • Biology, Medicine
  • Nucleic acids research
  • 2001 (First Publication: 15 May 2001)
  • In this study, we characterize the thermodynamics of hybridization, binding kinetics and conformations of four ribose-modified (2'-fluoro, 2'-O-propyl, 2'-O-methoxyethyl and 2'-O-aminopropyl)Expand
  • Matjaž Polak, M. Manoharan M. Manoharan, Gopal B. Inamati, Janez Plavec
  • Biology, Medicine
  • Nucleic acids research
  • 2003 (First Publication: 15 April 2003)
  • Conformational properties of trimeric and tetrameric 2',5'-linked oligonucleotides, 3'-MOE-A3(2',5') (1) and 3'-MOE-A4(2',5') (2), and their 3',5'-linked analogs, 2'-MOE-A3(3',5') (3) andExpand
    Abstract Recently our laboratory introduced1 chemistries to synthesize 2′- and 3′- cholesteroluridine conjugates which were incorporated into several antisense oligonucleotides. We have now extendedExpand