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Breast cancer is the leading cause of cancer-related mortality among females worldwide, and therefore the development of new therapeutic approaches is still needed. Rosemary (Rosmarinus officinalis L.) extract possesses antitumor properties against tumor cells from several organs, including breast. However, in order to apply it as a complementary(More)
5-Fluorouracil (5-FU) is the most used chemotherapeutic agent in colorectal cancer. However, resistance to this drug is relatively frequent, and new strategies to overcome it are urgently needed. The aim of this work was to determine the antitumor properties of a supercritical fluid rosemary extract (SFRE), alone and in combination with 5-FU, as a potential(More)
Colorectal and pancreatic cancers remain important contributors to cancer mortality burden and, therefore, new therapeutic approaches are urgently needed. Rosemary (Rosmarinus officinalis L.) extracts and its components have been reported as natural potent antiproliferative agents against cancer cells. However, to potentially apply rosemary as a(More)
Supercritical fluid extraction (SFE) is an innovative, clean and environmental friendly technology with particular interest for the extraction of essential oil from plants and herbs. Supercritical CO(2) is selective, there is no associated waste treatment of a toxic solvent, and extraction times are moderate. Further, supercritical extracts were often(More)
BACKGROUND Thymol (2-isopropyl-5-methylphenol) is the main monoterpene phenol found in thyme essential oil. This compound has revealed several biological properties, including antibacterial, anti-inflammatory and antioxidant activities. In this work, a comparison was made between the performance of different green solvents (ethanol, limonene and ethyl(More)
Tertiary to present deformation in the interior of the Iberian Peninsula reflects spatial and temporal variations of the activity of the plate boundaries. Local deformation patterns observed in many of the numerous intraplate Tertiary basins and their borders, such as the Madrid Basin and the Sierra de Altomira, are at first sight incompatible with the(More)
Three subsequent Tertiary paleostress fields that are deduced from fault-slip data for the eastern part of the Tajo Basin are analyzed by finite-element studies. The modelling results show that maximum horizontal stresses (S Hmax) are mainly controlled by the geometry of the model limits and the boundary conditions applied. The models are used to test two(More)
[1] Integration of stress indicator data, gravity data, crustal kinematics data, and analysis of topography and recent vertical motions demonstrates the occurrence of consistently oriented spatial patterns of large-scale Alpine to recent intraplate deformation in Iberia. The inferred upper crustal and lithospheric deformation patterns and the timing of the(More)
[1] The Iberian microcontinent and its connected oceanic crust are affected by deformations related to the Eurasian-African plate boundary. Active stress inversions from populations of moment tensor focal mechanisms have been performed around and inside the Iberian peninsula, using a total of 213 moment tensor estimates. Main results are as follows: (1) The(More)
Supercritical extraction was employed to produce rosemary (Rosmarinus officinalis L.) extracts with different composition and antioxidant activity. CO₂ was utilized as supercritical solvent and diverse extraction conditions (temperature, pressure, amount of cosolvent and fractionation scheme) were applied. The extracts with higher antioxidant content were(More)