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Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
TLDR
The finding that this family of demethylases generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation. Expand
Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution
TLDR
The X-ray crystal structure of Thermus aquaticus core RNA polymerase reveals a "crab claw"-shaped molecule with a 27 A wide internal channel that places key functional sites, defined by mutational and cross-linking analysis, on the inner walls of the channel in close proximity to the active center Mg2+. Expand
Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus.
TLDR
Sequence alignment and structural data indicate that the SarA protein family could be subdivided into three subfamilies: (1) single-domain proteins; (2) double- domain proteins; and (3) proteins homologous to the MarR protein family. Expand
Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester
TLDR
The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain, explaining how the activator promotes insertion of PKCs into membranes. Expand
SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway
TLDR
It is found that SARS-CoV enters cells via pH- and receptor-dependent endocytosis, and this finding contributes to the understanding of SARS -CoV pathogenesis, providing new information for anti-viral drug research. Expand
Structure of the adenylyl cyclase catalytic core
TLDR
F Forskolin appears to activate adenylyl cyclase by promoting the assembly of the active dimer and by direct interaction within the catalytic cleft, which is lined by charged residues implicated in ATP binding. Expand
Structural Insights into Histone Demethylation by JMJD2 Family Members
TLDR
Sited-directed mutagenesis in conjunction with demethylase activity assays allowed us to propose a molecular model for substrate selection by the JMJD2 histone dem methylase family. Expand
Interaction of JMJD6 with single-stranded RNA
TLDR
The structures of JMJD6 with and without α-ketoglutarate revealed a novel substrate binding groove and two positively charged surfaces, which suggest that JMJD 6 may bind and modify single-stand RNA rather than the previously reported peptide substrates. Expand
Structural basis of the recognition of a methylated histone tail by JMJD2A
TLDR
Structures of the JMJD2A catalytic core complexed with methylated H3K36 peptide substrates in the presence of Fe(II) and N-oxalylglycine are presented to provide insights into the mechanisms and specificity of histone demethylation. Expand
Crystal Structure of sTALL-1 Reveals a Virus-like Assembly of TNF Family Ligands
TLDR
The mutant sTALL-1 still bound its receptor but could not activate NF-kappaB and did not stimulate B lymphocyte proliferation, and it is proposed that this virus-like assembly of sTall-1 is the functional unit for TALL- 1 in vivo. Expand
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