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  • Goli Samimi, Roohangiz Safaei, +5 authors Stephen B. Howell
  • Biology, Medicine
  • Clinical Cancer Research
  • 2004 (First Publication: 15 July 2004)
  • Purpose: The goal of this study was to determine the effect of small changes in ATP7A expression on the pharmacodynamics of cisplatin, carboplatin, and oxaliplatin in human ovarian carcinoma cells.Continue Reading
  • Samuel C Mok, Tomas A. Bonome, +17 authors Michael J. Birrer
  • Biology, Medicine
  • Cancer cell
  • 2009 (First Publication: 1 December 2009)
  • Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized.Continue Reading
  • Alison Kay Holzer, Goli Samimi, +4 authors Stephen B. Howell
  • Biology, Medicine
  • Molecular Pharmacology
  • 2004 (First Publication: 1 October 2004)
  • Cells selected for resistance to cisplatin are often cross-resistant to copper and vice versa, and the major copper influx transporter copper transport protein 1 (CTR1) has been shown to regulate theContinue Reading
  • Goli Samimi, Daniel Roberto Fink, +4 authors Stephen B. Howell
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2000 (First Publication: 1 April 2000)
  • Preclinical studies have demonstrated a relationship between DNA mismatch repair (MMR) status and sensitivity to cisplatin and carboplatin. MMR-deficient cells are resistant to both drugs, andContinue Reading
  • Fatemeh Vafaee, Emily K. Colvin, Samuel C Mok, Viive M. Howell, Goli Samimi
  • Biology, Medicine
  • Scientific Reports
  • 2017 (First Publication: 4 September 2017)
  • Cancer-associated fibroblasts (CAFs) contribute to the poor prognosis of ovarian cancer. Unlike in tumour cells, DNA mutations are rare in CAFs, raising the likelihood of other mechanisms thatContinue Reading