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OBJECTIVE This study was undertaken to assess the twentieth-century literature on outcome in schizophrenia for historical trends that might be associated with changes in diagnostic and therapeutic practice and to test the hypothesis that both improved biological treatment and changes in diagnostic criteria have influenced outcome. METHOD Meta-analysis of(More)
The psychological, neuropsychological, and neurometabolic effects of the hallucinogenic agent mescaline were investigated in 12 normal men who were volunteers. Mescaline produced an acute psychotic state 3 1/2-4 hr after drug intake, as measured by the Brief Psychiatric Rating Scale (BPRS) and Paranoid Depression Scale (PDS). The Assessment of Altered(More)
In 15 patients with Huntington's disease, 17 offspring at risk and 63 healthy controls, visuomotor performances were assessed by quantitative (statistical) and qualitative analysis. The much enlarged error score of the nondominant left hand in patients with Huntington's disease was explained as callosal dyspraxia. Five of the 17 offspring revealed results(More)
Eye movements were investigated in 14 patients with manifest Huntington's Chorea, 10 offspring and 10 normal subjects with electronystagmography (ENG) and during REM sleep. In choretic patients the following abnormalities were found: 1. Voluntary saccades were slowed in 10 of 14 patients and were more disturbed in the vertical than the horizontal direction.(More)
The occurrence of H-reflexes over both the anterior tibial muscle and the thenar muscle on both sides was investigated in 15 patients suffering from Huntington's disease, 8 clinically inconspicuous offspring, and 30 healthy normal controls. The following results were obtained: 1. An obvious H-reflex over the anterior tibial muscle was found in 12 of 15(More)
In 13 patients suffering from Huntington's chorea (H.Ch.) VEPs and SSEPs were investigated in comparison with 9 clinically unaffected offsprings and 40 normal adults. (1) The mean amplitude of VEPs was reduced in all patients and in 4 out of 9 offsprings. (2) Latencies of P100 in VEPs were normal in all subjects. (3) The late components were reduced in(More)
In 8 patients with manifest Huntington's Chorea vestibulo-ocular (VOR) and cervico-ocular (COR) reflexes were compared with eye movements during active head turnings. Seated patients were stimulated with their eyes closed by sinusoidal swings around the vertical axis at frequencies of 0.05, 0.1 and 0.2s-1 with amplitudes of 20, 40 and 60 degrees. 1) With(More)
Three disorders of facial recognition and perception in acute schizophrenia and mescaline-induced psychosis are described and illustrated using original clinical and experimental material: "affective prosopagnosia" or stress-related dysfunctional face recognition; "physiognomization" of the environment or persistent illusions and hallucinations of(More)
The long-term consequences of partial callosal lesions were examined in 7 neurosurgically treated patients. Detailed clinical and neuropsychological assessment of the interhemispheric transfer (multimodal sensory and motor tasks) as well as memory and attention tests were used. The results revealed some disconnection symptoms with minor clinical(More)
While modern neuropsychological and electrophysiological studies claim a functional disturbance of the left hemisphere (LH) in schizophrenia, historical clinical and anatomical work rather points to the right hemisphere (RH) as the main site of psychosis. In the light of an interhemispheric functional balance of inhibition and release, LH-dysfunction in(More)