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OBJECTIVE This study was undertaken to assess the twentieth-century literature on outcome in schizophrenia for historical trends that might be associated with changes in diagnostic and therapeutic practice and to test the hypothesis that both improved biological treatment and changes in diagnostic criteria have influenced outcome. METHOD Meta-analysis of(More)
The psychological, neuropsychological, and neurometabolic effects of the hallucinogenic agent mescaline were investigated in 12 normal men who were volunteers. Mescaline produced an acute psychotic state 3 1/2-4 hr after drug intake, as measured by the Brief Psychiatric Rating Scale (BPRS) and Paranoid Depression Scale (PDS). The Assessment of Altered(More)
The purpose of this study was to investigate whether patients experiencing both a major psychiatric disorder and a concurrent substance abuse problem (dual diagnosis) manifest greater neuropsychological dysfunctions than patients experiencing a major psychiatric disorder alone. Differences in diagnostic variability and fluidity between dual diagnosis and(More)
In 15 patients with Huntington's disease, 17 offspring at risk and 63 healthy controls, visuomotor performances were assessed by quantitative (statistical) and qualitative analysis. The much enlarged error score of the nondominant left hand in patients with Huntington's disease was explained as callosal dyspraxia. Five of the 17 offspring revealed results(More)
The influence of Piracetam on Parkinsonism was studied in 18 patients and 18 matched controls. Clinical, visuomotor and psychometric variables were measured. Piracetam improved visuomotor reaction time (RT) and accuracy in 6 mildly affected and tracing time in 6 moderately affected patients, the clinical condition and the organic brain syndrome in all(More)
Eye movements were investigated in 14 patients with manifest Huntington's Chorea, 10 offspring and 10 normal subjects with electronystagmography (ENG) and during REM sleep. In choretic patients the following abnormalities were found: 1. Voluntary saccades were slowed in 10 of 14 patients and were more disturbed in the vertical than the horizontal direction.(More)
Striatal and cortical atrophy are significant features in the pathology of Huntington's chorea (HCh). A correlative study revealed that the CT findings of atrophy in HCh (8 patients) parallel the clinical and neurophysiological findings. In offspring (8 subjects) of HCh patients, however, the CT changes were insignificant although neurophysiological data(More)
Since the classic descriptions of the course of bipolar and recurrent depressive forms of manic-depressive illness by Emil Kraepelin a century ago, it has been considered a truism that the rate of cycling increases, and wellness intervals shorten, with rising counts of recurrences, particularly early in the natural history of the illness. Less well known is(More)
In 13 patients suffering from Huntington's chorea (H.Ch.) VEPs and SSEPs were investigated in comparison with 9 clinically unaffected offsprings and 40 normal adults. (1) The mean amplitude of VEPs was reduced in all patients and in 4 out of 9 offsprings. (2) Latencies of P100 in VEPs were normal in all subjects. (3) The late components were reduced in(More)
Three disorders of facial recognition and perception in acute schizophrenia and mescaline-induced psychosis are described and illustrated using original clinical and experimental material: "affective prosopagnosia" or stress-related dysfunctional face recognition; "physiognomization" of the environment or persistent illusions and hallucinations of(More)