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Protein modification by small ubiquitin-related modifier proteins (SUMOs) controls diverse cellular functions. Dysregulation of SUMOylation or deSUMOylation processes has been implicated in the development of cancer and neurodegenerative diseases. However, no small-molecule inhibiting protein SUMOylation has been reported so far. Here, we report inhibition(More)
Heparanase is an endo-beta-D-glucuronidase that degrades heparan sulfate glycosaminoglycans in the extracellular matrix and the basement membrane and is well known to be involved in tumor cell invasion and angiogenesis. We have focused on heparanase as a target for antitumor agents, especially antimetastatic agents.(More)
Oseltamivir (Tamiflu) and zanamivir (Relenza), two extensively used clinically effective anti-influenza drugs, are viral sialidase (also known as neuraminidase) inhibitors that prevent the release of progeny virions and thereby limit the spread of infection. Recently mortalities and neuropsychiatric events have been reported with the use of oseltamivir,(More)
Nylen and Omnell (1962) were the first who described parallel 8.2 A. striations in an electron micrograph of a Iongltudinally-sectioned enamel crystallltes. They considered this phenomenon as Bragg reflections~ a reflectlon of electrons in a pattern caused by atomic planes in parallel arrangement. Takuma, one of the present authors, has made many(More)
Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators. While the structure of zoanthamines, especially the ABC-ring portion, is similar to that of steroids, the CDEFG-ring portion, composed of aminoacetal and lactone core, is a unique structural element. In this report, we(More)
Scanning electron microscopy of a submandibular sialolith showed octahedral and dipyramidal crystals located at the surface layer of cortex. The crystal habits observed were consistent with those of a tetragonal crystal system. X-ray microdiffraction revealed the presence of weddellite. The origin of weddellite within the calculus remains to be determined.
A case of adenomatoid odontogenic tumor involving the right upper cuspid region of a 17-year-old girl is described. In light microscopy, liminal structures and rosette-like structures were found in the parenchyma of the tumor. Electron microscopic observations revealed that the rosette-like structures were less organized than the luminal structures; the(More)