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PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to generate a hepatocyte-specific null mutation of Pten in mice (AlbCrePten(flox/flox) mice). AlbCrePten(flox/flox) mice showed massive hepatomegaly and steatohepatitis with triglyceride(More)
We have found that tissue-type transglutaminase (tTG), also called TGc, TGase2 and Galpha(h), has the activity of protein disulphide isomerase (PDI). We have shown that tTG converts completely reduced/denatured inactive RNase A molecule to the native active enzyme. The PDI activity of tTG was strongly inhibited by bacitracin, which is a frequently used(More)
a Faculty of Economics, Osaka University, 1-7, Machikaneyama, Toyonaka, Osaka 560, Japan E-mail: hasegawa@econ.osaka-u.ac.jp b Department of Infomatics and Mathematical Science, Graduate School of Engineering Science, Osaka University, 1-3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan E-mail: murata@ics.es.osaka-u.ac.jp c Department of Infomatics and(More)
Cholesterol homeostasis is maintained by coordinate regulation of cholesterol synthesis and its conversion to bile acids in the liver. The excretion of cholesterol from liver and intestine is regulated by ATP-binding cassette half-transporters ABCG5 and ABCG8. The genes for these two proteins are closely linked and divergently transcribed from a common(More)
According to the past researches, a TCP Vegas version is able to achieve higher throughput than TCP Tahoe and Reno versions, which are widely used in the current Internet. However, we need to consider a migration path for TCP Vegas to be deployed in the Internet. By focusing on the situation where TCP Reno and Vegas connections share the bottleneck link, we(More)
PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease. We used the Cre-loxP system to generate an endothelial cell-specific mutation of Pten (Tie2CrePten) in mice. Tie2CrePten(flox/+) mice displayed enhanced tumorigenesis due to an increase in angiogenesis driven by vascular(More)
We investigate the performance of TCP under three representatives of packet scheduling algorithms at the router. Our main focus is to investigate how fair service can be provided for elastic applications sharing the link. Packet scheduling algorithms that we consider are FIFO (First In First Out), RED (Random Early Detection), and DRR (Deficit Round Robin).(More)
The continuing and explosive growth of the Internet has shown that current TCP mechanisms cannot achieve efficient utilization of networks with large bandwidth-delay products. To address this problem, we propose an enhanced transport-layer protocol called gHSTCP, which is based on the HighSpeed TCP proposed by S. Floyd (see RFC 3649, 2003). By monitoring(More)
Kupffer cells are the largest population of tissue macrophages. They are predominantly distributed in the lumen of hepatic sinusoids and exhibit endocytic activity against blood-borne materials entering the liver. Macrophage colony-stimulating factor and other growth factors regulate Kupffer cell differentiation in the fetal and adult period. Because of the(More)
We introduce a novel mechanism for actively measuring available bandwidth along a network path. Instead of adding probe traffic to the network, the new mechanism exploits data packets transmitted in a TCP connection (inline measurement). We first introduce a new bandwidth measurement algorithm that can perform measurement estimates quickly and continuously(More)