Gm Rubin

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It is now apparent that in men and in postmenopausal women, estrogens have important physiological and pathophysiological roles. However, importantly, these actions are at a local level, namely paracrine, autocrine, and even 'intracrine' rather than endocrine in the classical sense. Thus for example local estrogen biosynthesis in the bones of men plays a(More)
Natural (human) and experimental (mouse) models of estrogen insufficiency have revealed hitherto unexpected roles for estrogens in both males and females. In postmenopausal women, and in men, estrogen no longer has a major role as a circulating hormone, but rather it functions locally as a paracrine or even 'intracrine' factor in tissue sites where it is(More)
tification of gene regulatory networks by strategic gene disruptions and gene overexpressions. A system for identifying genetic networks from gene expression patterns produced by gene disruptions and overexpressions. approach to reconstructing genetic regulatory networks with hidden factors. [9] Allister Bernard and Alexander J Hartemink. Informative(More)
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