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Voltage-gated and ligand-gated ion channels are used in eukaryotic organisms for the purpose of electrochemical signaling. There are prokaryotic homologues to major eukaryotic channels of these sorts, including voltage-gated sodium, potassium, and calcium channels, Ach-receptor and glutamate-receptor channels. The prokaryotic homologues have been less well(More)
As the pace of implementing personalized medicine concepts increases, high-throughput variant calling on hundreds of individual genomes per day is a reality that will likely be faced by sequencing facilities across the country in the near future. While the scientific best practices for human variant calling workflows have been well defined, they also pose(More)
As the pace of implementing personalized medicine concepts increases, high-throughput variant calling on hundreds of individual genomes per day is a reality that will likely be faced by sequencing facilities across the country in the near future. While the scientific best practices for human variant calling workflows have been well defined, they also pose(More)
Using high performance computing and domain-based functional annotation of proteins to enhance discovery of novel proteins, identify functional homology, and characterize phylogenetic relatedness Abstract Background
The MotifNetwork system is a high performance system for the fast scanning and interpretation of large numbers of proteins into their constituent domains. Once transformed into a domain dataset, several levels of analysis such as domain-domain and protein-protein co-location graphs are constructed. These basic data products form the beginning of a(More)
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