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The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly, cells and tissues from p27 null mice, including brain,(More)
OBJECTIVE Ghrelin is a stomach-derived peptide that increases food intake through the activation of hypothalamic AMP-activated protein kinase (AMPK). However, the molecular mechanisms initiated by the activation of the ghrelin receptor, which in turn lead to AMPK activation, remain unclear. Sirtuin 1 (SIRT1) is a deacetylase activated in response to calorie(More)
BACKGROUND AND OBJECTIVES Damage to peripheral nerves provokes chronic neuropathic pain that lasts beyond the duration of the nerve injury. The presence of pain signs have been reported in areas other than those attributed to the injured nerve, i.e., in contralateral regions. We evaluated the presence, magnitude, and chronology of mechanical and cold(More)
Processes in healthcare and socio-assistive domains typically span multiple institutions and require cooperation and information exchange among multiple IT systems. In most cases this cooperation today is handled " manually " via document exchange (by email, post, or fax) and in a point-to-point fashion. One of the reasons that makes it difficult to(More)
Assistive processes in healthcare and socio-assistive domains typically span multiple institutions which usually communicate manually with the exchange of documents. Despite the needs of cooperation it is difficult to provide an integrated solution to improve data exchange and allow comprehensive monitoring of the processes due to the complexity of the(More)
Adipose tissue is essential in the regulation of body weight. The key process in fat catabolism and the provision of energy substrate during times of nutrient deprivation or enhanced energy demand is the hydrolysis of triglycerides and the release of fatty acids and glycerol. Nur77 is a member of the NR4A subfamily of nuclear receptors that plays an(More)
Traditional university and college students ages 18–24 are traversing an important period in their lives in which behavioral intervention is critical in reducing their risk of cancer in later years. The study's purpose was to determine the perceptions and level of knowledge about cancer of white, Hispanic, and black university students (n = 958). Sources of(More)
The retinoblastoma protein Rb is a tumor suppressor involved in cell cycle control, differentiation, and inhibition of oncogenic transformation. Besides these roles, additional functions in the control of immune response have been suggested. In the present study we investigated the consequences of loss of Rb in viral infection. Here we show that virus(More)