Gloria Martín-Serrano

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BACKGROUND AND OBJECTIVE Romiplostim and eltrombopag are thrombopoietin receptor (TPOr) agonists that promote megakaryocyte differentiation, proliferation and platelet production. In 2012, a systematic review and meta-analysis reported a non-statistically significant increased risk of thromboembolic events for these drugs, but analyses were limited by lack(More)
BACKGROUND The pattern of use of antidepressive drugs in Spain through 1985-1994 is studied. Special emphasis is given to the impact of selective serotonin re-uptake inhibitors introduction at the end of the eighties. MATERIAL AND METHODS Information on drug utilization was obtained from the databases of the Ministry of Health which contain the number of(More)
BACKGROUND Previous work has suggested that dual blockade using inhibitors of the renin-angiotensin system (RAS) would be associated with an increase in side effects compared to monotherapy. We reexamined the safety of dual RAS blockade, especially in patients at risk, and explored the stability of the evidence accumulated over the years. METHOD(More)
The variations in QRS-T configurations in both standard and precordial leads from control rat electrocardiograms are analysed in this study. The durations of the above mentioned QRS complex, T and Q waves and the QT interval are also described. Many of the observed differences in rat electrocardiograms are due to a series of factors that may include(More)
OBJECTIVE Data on meningococcal vaccines safety are scanty. In 1997 several vaccination campaign took place in Spain. Thus, this situation was used to improve our knowledge about the safety profile of this vaccine. METHODS An inquiry was carried out to the Regional Centers of the Spanish Pharmacovigilance System to know the number of vaccinated people and(More)
We read with great interest the scientific letter recently published in your journal by Consuegra-Sánchez et al. entitled ‘‘Increased mortality in patients with diabetes associated with olmesartan for the prevention/delay of microalbuminuria onset: a matter of concern?’’ The authors presented a meta-analysis of randomized clinical trials with placebo(More)
BACKGROUND In 1997 a program was set up to improve the use of ticlopidine. In the present study we assess whether this objective was achieved. PATIENTS AND METHODS We carried out a pharmacy-based cross-sectional study. RESULTS Out of 346 patients interviewed, 56% presented an off-label indication for ticlopidine. In 23% of patients the daily dose used(More)
BACKGROUND This study has analysed the trend of antihypertensive drugs consumption in Spain from 1985 to 1995, its economical impact and the correlation with the available scientific evidence. The utilization of calcium channel blockers in the context of the recent controversial about their safety profile was also evaluated. METHODS Drugs from the ATC(More)
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