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The nematode Caenorhabditis elegans offers a promising system for the reductionist study of learning and memory. In this article, classical conditioning in C. elegans is demonstrated with a variety of associative learning assays. These assays allowed for the isolation and behavioral characterization of 2 mutant C. elegans lines impaired in associative(More)
BACKGROUND The predictors and causes of stroke after valvular surgery are incompletely defined. We examined the incidence, predictors, and mechanisms of stroke during valvular procedures over a 15-year time period. METHODS AND RESULTS We retrospectively reviewed prospectively gathered data on 5954 consecutive patients undergoing valvular procedures at our(More)
OBJECTIVE To identify regional differences in recommendations for radioactive iodine remnant ablation (RRA) in early stage well-differentiated thyroid carcinoma (WDTC) within Canada and the United States. DESIGN A cross-sectional written survey of a sample of physicians in specialties potentially involved in thyroid cancer care was performed in 2006.(More)
OBJECTIVE To explore issues of medical professionalism in the context of severe acute respiratory syndrome (SARS), a new emerging health threat. DESIGN Qualitative interviews analysed with grounded theory methodology. SETTING University hospitals in Toronto, Canada, during the SARS outbreak in 2003. PARTICIPANTS 14 staff physicians from divisions of(More)
Endocrine oncology is a complex area that must determine the site of a neoplastic process and the hormonal dysregulation that ensues. Patients with endocrine tumors often have delayed diagnosis because of the nonspecific and often subtle signs and symptoms. In patients with multiple endocrine neoplasia syndromes, diagnosis and clinicopathologic correlations(More)
Fine-needle aspiration (FNA) is a procedure that is increasingly being performed. Artefacts occurring after FNA are reported to complicate the histological analysis of the tissue, mainly in the thyroid; WHAFFT (worrisome histologic alterations following FNA of thyroid) is well documented in the literature. The case of a male patient with hypercalcaemia who(More)
Mrs. Carter is a 51-year-old woman who presents to the emergency department (ED) complaining of shortness of breath and chest pain. This previously healthy woman was well up until last evening, when she experienced acute pleuritic chest pain. The sensation of difficulty breathing developed shortly thereafter and progressed throughout the night. Mrs. Carter(More)
OBJECTIVE To identify clinical variables associated with the presence of a structurally advanced sellar mass (ASM). METHODS We performed a retrospective study of patients referred for evaluation of suspected new pituitary disease or sellar mass to the Endocrine Oncology Unit of Mount Sinai Hospital in Toronto, Ontario, Canada. By multivariate analysis, we(More)
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