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Brain arteriovenous malformations (BAVMs) can cause lethal hemorrhagic stroke and have no effective treatment. The cellular and molecular basis for this disease is largely unknown. We have previously… (More)
Proper fibroblast cell migration and differentiation are critical for valve formation and homeostasis, but uncontrolled myofibroblastic activation may precede osteogenic differentiation and… (More)
help to shrink AVMs and may be a new approach to treating AVMs and other vascular diseases. These findings suggest that strategies to manipulate Notch receptor signaling in blood vessel endothelial… (More)
In the process of designing and field-testing bioinformatics curriculum materials, we have adopted a three-stage, progressive model that emphasizes collaborative scientific inquiry. The elements of… (More)
Abnormally enlarged blood vessels underlie many life-threatening disorders including arteriovenous (AV) malformations (AVMs). The core defect in AVMs is high-flow AV shunts, which connect arteries… (More)