Gloria Isani

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Metallothioneins (MTs) (I+II) play pivotal roles in metal-related cell homeostasis because of their high affinity for metals forming clusters. The main functional role of MTs is to sequester and/or dispense zinc participating in zinc homeostasis. Consistent with this role, MT gene expression is transcriptionally induced by a variety of stressing agents to(More)
Thymic atrophy or thymus absence causes depressed thyroid-thymus axis (TTA) efficiency in old, young propyl-thiouracil (PTU) (experimental hypothyroidism) and in young-adult thymectomised (Tx) mice, respectively. Altered zinc turnover may be also involved in depressed TTA efficiency. Zinc turnover is under the control of zinc-bound metallothioneins (Zn-MTs)(More)
Metallothioneins (MTs) are ubiquitous low molecular weight cysteine-rich proteins characterized by high affinity for d10 electron configuration metals, including essential (Zn and Cu) and non-essential (Cd and Hg) trace elements. The biological role of these ancient and well-conserved multifunctional proteins has been debated since MTs were first discovered(More)
In the present paper we present results of an investigation of the myofibrillar composition and pyruvate kinase (PK) activity in the white portion of lateral muscle of gilthead sea bream fed a commercial diet for five months during juvenile growth. The zinc and copper content of muscle and liver were also measured. Myofibrillar proteins extracted from the(More)
Two groups of young gilthead sea bream were fed two different diets: a control diet containing Zn at 120 mg/kg feed and a supplemented diet containing Zn at 240 mg/kg feed. White portions of lateral muscle were analyzed for Zn and Cu concentrations, myofibrillar composition and pyruvate kinase (PK) activity in order to determine the influence of Zn on these(More)
Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological(More)
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