Glenn P. Johnson

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RATIONALE Lithium, an effective psychotropic agent, affects membrane phospholipid metabolism, interferes with phosphoinositide signal transduction, and antagonizes the biological activity of calcium, all major factors of protein kinase C (PKC) activation. Consequently, lithium may interfere with cellular functions requiring PKC. Supporting this hypothesis,(More)
Mitogen-activated protein kinases (MAPKs) play important roles in cell proliferation, differentiation, and apoptosis. Important functional roles for MAPKs in postmitotic cells have recently been suggested. In the present study, we investigated the effect of aging on the brain ERK (extracellular signal-regulated kinase) and p38 MAPK signaling pathways of(More)
  • S C Smith, J D Lee, W J Bloss, G P Johnson, T Ingham, D E Heard
  • 2006
OH and HO 2 concentrations were measured simultaneously at the Mace Head Atmospheric Research Station in the summer of 2002 during the NAMBLEX (North Atlantic Marine Boundary Layer EXperiment) field campaign. OH was measured by laser-induced fluorescence employing the FAGE (Fluorescence Assay by Gas Expansion) technique, with a mean daytime detection limit(More)
  • D E Heard, K A Read, J Methven, S Al-Haider, W J Bloss, G P Johnson +61 others
  • 2006
A wide range of state-of-the-art instrumentation enabled detailed measurements of the boundary layer structure and atmospheric composition in the gas and aerosol phase to be made, providing one of the most comprehensive in situ studies of the marine boundary layer to date. This overview paper describes the aims of the NAMBLEX project in the context of(More)
  • S C Smith, J D Lee, W J Bloss, G P Johnson, D E Heard
  • 2005
OH and HO 2 concentrations were measured simultaneously at the Mace Head Atmospheric Research Station in the summer of 2002 during the NAMBLEX (North Atlantic Marine Boundary Layer EXperiment) field campaign. OH was measured by laser-induced fluorescence employing the FAGE (Fluorescence Assay by Gas Expansion)
The HF/6-31G * level of theory was used to calculate relaxed potential energy surfaces for 12 analogs of disaccharides. The analogs were made by replacing glucose with tetrahydropyran and fructose with 2-methyltetrahydrofuran. Molecules had zero, one or two anomeric carbon atoms, and di-axial, axial-equatorial, and di-equatorial linkages. Despite the(More)
This paper focuses on the methods used to construct Ramachandran plots for disaccharides. Our recent work based on a hybrid of molecular mechanics and quantum mechanics energies pointed to the need to take extra care when making these maps. Care is also important in the quantitative validation of these energy surfaces with linkage conformations that were(More)
Utilization of a manual sampling function as an alternative to the automatic sampling function in the Alco-Sensor IV Black Dot Model has been recognized by the manufacturer to potentially underestimate an individual's true breath alcohol content (BrAC). A controlled human subject study was conducted to analyze the possible breath-sampling differences(More)
  • D E Heard, K A Read, J Methven, S Al-Haider, W J Bloss, G P Johnson +60 others
  • 2002
between 23 July and 4 September 2002. A wide range of state-of-the-art instrumenta-tion enabled detailed measurements of the boundary layer structure and atmospheric 5 composition in the gas and aerosol phase to be made, providing one of the most comprehensive in situ studies of the marine boundary layer to date. This overview paper describes the aims of(More)
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