Glenn Matthew Eastwood

Learn More
INTRODUCTION Hyperoxia has recently been reported as an independent risk factor for mortality in patients resuscitated from cardiac arrest. We examined the independent relationship between hyperoxia and outcomes in such patients. METHODS We divided patients resuscitated from nontraumatic cardiac arrest from 125 intensive care units (ICUs) into three(More)
Early hyperoxia may be an independent risk factor for mortality in mechanically ventilated intensive care unit (ICU) patients. We examined the relationship between early arterial oxygen tension (PaO2) and in-hospital mortality. We retrospectively assessed arterial blood gases (ABG) with ‘worst’ alveolar-arterial (A-a) gradient during the first 24 h of ICU(More)
BACKGROUND Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with intermittent bolus dosing standard therapy, despite a strong theoretical rationale for continuous administration. The aim of this trial was to determine the clinical and pharmacokinetic differences between continuous and intermittent dosing in patients with severe(More)
BACKGROUND Extended daily dialysis (EDD) has been suggested as an effective renal replacement therapy for acute kidney injury. However, results from studies comparing EDD to continuous renal replacement therapy (CRRT) are inconclusive. STUDY DESIGN A systematic review and meta-analysis was performed by searching in MEDLINE, EMBASE, the Cochrane Library,(More)
PURPOSE It is controversial whether all critically ill patients with risk, injury, failure, loss, and end-stage renal failure (RIFLE) F class acute kidney injury (AKI) should receive renal replacement therapy (RRT). We reviewed the outcome of open heart surgery patients with severe RIFLE-F AKI who did not receive RRT. MATERIALS AND METHODS We identified(More)
OBJECTIVES To assess the feasibility and safety of a conservative approach to oxygen therapy in mechanically ventilated ICU patients. DESIGN Pilot prospective before-and-after study. SETTING A 22-bed multidisciplinary ICU of a tertiary care hospital in Australia. PATIENTS A total of 105 adult (18 years old or older) patients required mechanical(More)
RATIONALE Continuous infusion of β-lactam antibiotics may improve outcomes because of time-dependent antibacterial activity compared with intermittent dosing. OBJECTIVES To evaluate the efficacy of continuous versus intermittent infusion in patients with severe sepsis. METHODS We conducted a randomized controlled trial in 25 intensive care units (ICUs).(More)
BACKGROUND There is little information on the use of paracetamol for septic critically ill patients. We hypothesised that paracetamol use is common in such patients, but its administration is not predictably related to body temperature. OBJECTIVE To study the epidemiology and associations of paracetamol use in a cohort of septic critically ill patients.(More)
Different molecular forms of urinary neutrophil gelatinase-associated lipocalin (NGAL) have recently been discovered. We aimed to explore the nature, source and discriminatory value of urinary NGAL in intensive care unit (ICU) patients. We simultaneously measured plasma NGAL (pNGAL), urinary NGAL (uNGAL), and estimated monomeric and homodimeric uNGAL(More)
Intensivists frequently prescribe oxygen therapy for critically ill patients, however little is known about how intensivists manage oxygen therapy, or what factors influence their decisions. We surveyed intensivists listed on the Australian and New Zealand Intensive Care Society Clinical Trials Group database to investigate how intensivists report their(More)