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RATIONALE Continuous infusion of β-lactam antibiotics may improve outcomes because of time-dependent antibacterial activity compared with intermittent dosing. OBJECTIVES To evaluate the efficacy of continuous versus intermittent infusion in patients with severe sepsis. METHODS We conducted a randomized controlled trial in 25 intensive care units (ICUs).(More)
PURPOSE Early hyperoxia may be an independent risk factor for mortality in mechanically ventilated intensive care unit (ICU) patients. We examined the relationship between early arterial oxygen tension (PaO(2)) and in-hospital mortality. METHOD We retrospectively assessed arterial blood gases (ABG) with 'worst' alveolar-arterial (A-a) gradient during the(More)
INTRODUCTION Hyperoxia has recently been reported as an independent risk factor for mortality in patients resuscitated from cardiac arrest. We examined the independent relationship between hyperoxia and outcomes in such patients. METHODS We divided patients resuscitated from nontraumatic cardiac arrest from 125 intensive care units (ICUs) into three(More)
BACKGROUND Intensivists frequently prescribe proton pump inhibitors (PPIs) or histamine-2 receptor blockers (H2RBs) to intensive care unit patients for stress ulcer prophylaxis (SUP). Despite the common use of SUP medicines, there is limited high-level evidence to support the choice between them. AIM To describe self-reported practice of SUP by Australian(More)
BACKGROUND In mechanically ventilated (MV) cardiac arrest (CA) survivors admitted to the intensive care unit (ICU) avoidance of hypoxia is considered crucial. However, avoidance of hyperoxia may also be important. A conservative approach to oxygen therapy may reduce exposure to both. METHODS We evaluated the introduction of conservative oxygen therapy(More)
BACKGROUND Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with intermittent bolus dosing standard therapy, despite a strong theoretical rationale for continuous administration. The aim of this trial was to determine the clinical and pharmacokinetic differences between continuous and intermittent dosing in patients with severe(More)
INTRODUCTION In this study, we aimed to examine the association between paracetamol administration in the intensive care unit (ICU) and mortality in critically ill patients. METHODS We conducted a multicenter retrospective observational study in four ICUs. We obtained information on paracetamol use, body temperature, demographic, clinical and outcome data(More)
OBJECTIVE To describe the duration of fever, fever management, and outcomes among intensive care patients with fever and known or suspected infection. DESIGN, SETTING AND PARTICIPANTS Prospective observational trial in three tertiary intensive care units over 6 weeks in 2010. Adult patients were screened for eligibility and inclusion if they had a fever(More)
BACKGROUND There is little information on the use of paracetamol for septic critically ill patients. We hypothesised that paracetamol use is common in such patients, but its administration is not predictably related to body temperature. OBJECTIVE To study the epidemiology and associations of paracetamol use in a cohort of septic critically ill patients.(More)
Intensivists frequently prescribe oxygen therapy for critically ill patients, however little is known about how intensivists manage oxygen therapy, or what factors influence their decisions. We surveyed intensivists listed on the Australian and New Zealand Intensive Care Society Clinical Trials Group database to investigate how intensivists report their(More)