Glenn G. Whiteside

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Transfection and subsequent expression of DNA in living neuronal tissue is problematic and no technique has emerged that is completely non-damaging, efficient and reproducible. The Bio-Rad hand-held Gene Gun has overcome some of these problems by exploiting a biolistic method in which small gold particles carrying plasmid DNA are propelled into neurons(More)
Mogamulizumab (Poteligeo®) is a defucosylated, humanized monoclonal antibody targeting CC chemokine receptor 4 (CCR4). Development is being carried out by its owner Kyowa Hakko Kirin for various haematological malignancies, and by licensee Amgen for asthma. Mogamulizumab was conceived through Kyowa Hakko Kirin's Potelligent® technology, which produces(More)
Vivus' proprietary oral capsule containing phentermine and extended-release (ER) topiramate has been approved in the US for the treatment of obesity. Phentermine is an appetite suppressant, while topiramate is an anti-epileptic medication. The once-daily formulation, known as Qsymia™, is designed to produce weight loss by decreasing appetite and increasing(More)
Amsacrine (4'-(9-acridinylamino)methanesulphon-m-anisidide) is an antileukemic drug which inhibits topoisomerase II (topo II) enzymes. We studied effects of two concentrations of amsacrine on the GM10115A cell line. This is a Chinese hamster line containing a single human chromosome 4, which can be readily visualised using fluorescence in situ hybridisation(More)
The first article (Yu, Mylopoulos & Lesperance, 1996), reviews three process modeling methods, Strategic Dependency, Strategic Rationale, and Business Process and their associated tools. The second article (Kueng & Kawalek, 1997) makes several key points that process models are only a burden if they are misunderstood, implemented poorly, and contribute(More)
Department of Internal Medicine (AMLL), & Dept. of Anesthesia (RM, GW), Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK Dept. of Chemistry (CA, MF), University of Cambridge, Cambridge, UK SynGenix LTD, Cambridge, UK (AGF, GW, MB, MF) Museum of Comparative Zoology and Department of Anthropology, Harvard University, Cambridge, MA (AGF, TWD,(More)
The clinical antitumor efficacy of nitrogen mustards such as chlorambucil may relate to their ability to cause programmed cell death (apoptosis), probably through their DNA cross-linking properties. In contrast, bisbenzimidazoles such as Hoechst 33342 interact noncovalently with the minor groove of DNA, and appear to cause apoptosis in a fundamentally(More)