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Effect of Hydroxypropyl-β-Cyclodextrin on the Solubility of an Antiarrhythmic Agent
The aim of this work was to obtain an inclusion complex between HP-β-CD and amiodarone in order to increase the solubility of this active agent. Drug–cyclodextrin interactions in solution were
Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study
A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced
A HPLC Method for the Determination of Bisoprolol in Tablets and its Application to a Bioequivalence Study
TLDR
This paper presents the results of a six-month study of the phytochemical fingerprinting technique, developed in Iasi during the period of May 21 to 29, 2013.
Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone
The aim of this study was to improve the solubility of amiodarone hydrochloride (AMD) and the drug release using its inclusion complexes with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). The inclusion
A New and Sensitive LC-MS/MS Method for the Determination of Clopidogrel in Human Plasma
TLDR
The proposed method has been validated for a linear range of 10-10000 mg/mL and the value of the regression coefficient was ≥0.99 and can be used for the therapeutic drug monitoring of clopidogrel.
[Membrane-selective electrode for atropine assay].
TLDR
This electrode was used with good results for quantitative assay by direct potentiometry and potentiometric titration of atropine sulphate from pharmaceutical formulations, and has a linear response in the concentration range of 10(-2)-10(-5) M atropin sulphate.
OPTIMIZATION OF THE PREPARATION OF KOLLIDON SR-BASED AMIODARONE HYDROCHLORIDE TABLETS WITH SUSTAINED RELEASE.
TLDR
Chitosan, a natural polysaccharide with superior hydrating and absorbing properties was used in the formulation stage to optimize the release characteristics of those matrix tablets to develop formulations of AMD-HCl with optimal release characteristics.
Validation of a spectrophotometric assay method for bisoprolol using picric acid.
TLDR
The proposed and validated spectrophotometric method for the determination of bisoprolol is simple and cost effective.
Visible spectrophotometric method for amiodarone.
TLDR
The spectrophotometric method for the assay of amiodarone established established found the compound was most stable in a mixture of ethylic alcohol and water and it had an absorption maximum at 725 nm.
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