Gladiola Țântaru

Publications51
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Citations135
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Effect of Hydroxypropyl-β-Cyclodextrin on the Solubility of an Antiarrhythmic Agent
The aim of this work was to obtain an inclusion complex between HP-β-CD and amiodarone in order to increase the solubility of this active agent. Drug–cyclodextrin interactions in solution were…
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Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study
A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced…
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A HPLC Method for the Determination of Bisoprolol in Tablets and its Application to a Bioequivalence Study
TLDR
This paper presents the results of a six-month study of the phytochemical fingerprinting technique, developed in Iasi during the period of May 21 to 29, 2013.
Schiff bis bases: analytical reagents. II. Spectrophotometric determination of manganese from pharmaceutical forms.
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Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone
The aim of this study was to improve the solubility of amiodarone hydrochloride (AMD) and the drug release using its inclusion complexes with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). The inclusion…
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A New and Sensitive LC-MS/MS Method for the Determination of Clopidogrel in Human Plasma
TLDR
The proposed method has been validated for a linear range of 10-10000 mg/mL and the value of the regression coefficient was ≥0.99 and can be used for the therapeutic drug monitoring of clopidogrel.
[Membrane-selective electrode for atropine assay].
TLDR
This electrode was used with good results for quantitative assay by direct potentiometry and potentiometric titration of atropine sulphate from pharmaceutical formulations, and has a linear response in the concentration range of 10(-2)-10(-5) M atropin sulphate.
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OPTIMIZATION OF THE PREPARATION OF KOLLIDON SR-BASED AMIODARONE HYDROCHLORIDE TABLETS WITH SUSTAINED RELEASE.
TLDR
Chitosan, a natural polysaccharide with superior hydrating and absorbing properties was used in the formulation stage to optimize the release characteristics of those matrix tablets to develop formulations of AMD-HCl with optimal release characteristics.
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Validation of a spectrophotometric assay method for bisoprolol using picric acid.
TLDR
The proposed and validated spectrophotometric method for the determination of bisoprolol is simple and cost effective.
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Visible spectrophotometric method for amiodarone.
TLDR
The spectrophotometric method for the assay of amiodarone established established found the compound was most stable in a mixture of ethylic alcohol and water and it had an absorption maximum at 725 nm.
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