Giuseppina D’Alessandro

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Miriam Sciaccaluga, Bernard Fioretti, Luigi Catacuzzeno, Francesca Pagani, Cristina Bertollini, Maria Rosito, Myriam Catalano, Giuseppina D’Alessandro, Antonio Santoro, Giampaolo Cantore, Davide Ragozzino, Emilia Castigli, Fabio Franciolini, and Cristina Limatola Istituto Pasteur-Fondazione Cenci Bolognetti and Department of Physiology and Pharmacology, and(More)
Microglial cells participate in brain development and influence neuronal loss and synaptic maturation. Fractalkine is an important neuronal chemokine whose expression increases during development and that can influence microglia function via the fractalkine receptor, CX3CR1. Mice lacking Cx3cr1 show a variety of neuronal defects thought to be the result of(More)
Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the(More)
Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated. We report that EE exposure affects: (i) tumour size, increasing mice survival; (ii) glioma establishment, proliferation and invasion; (iii) microglia/macrophage (M/Mφ) activation; (iv) natural(More)
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