Giuseppe Toscano

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Transforming growth factor-β1 (TGF-β1) is a neurotrophic factor that exerts neuroprotective effects against β-amyloid-induced neurodegeneration. Recently, a specific impairment of the TGF-β1 signaling pathway has been demonstrated in Alzheimer's disease (AD) brain. TGF-β1 is also involved in the pathogenesis of depressive disorders, which may occur in(More)
Lyme disease, or borreliosis, is a zoonosis transmitted by Borrelia burgdorferi which also involves the central nervous system (CNS), in 15% of affected individuals, with the occurrence of aseptic meningitis, fluctuating meningoencephalitis, or neuropathy of cranial and peripheral nerves. Encephalopathy with white matter lesions revealed by magnetic(More)
The discovery of Epidermal Growth Factor Receptor (EGFR) mutations in Non Small Cell Lung Cancer (NSCLC) launched the era of personalized medicine in advanced NSCLC, leading to a dramatic shift in the therapeutic landscape of this disease. After ten years from the individuation of activating mutations in the tyrosine kinase domain of the EGFR in NSCLC(More)
The purposes of this study were to validate the use of a single standard question for the rapid screening of restless legs syndrome (RLS) and to analyze the eventual effects of the presence of RLS on self-assessed daytime sleepiness, global clinical severity and cognitive functioning. We evaluated a group of 521 consecutive patients who accessed our(More)
Until recently, few therapeutic options were available for patients with castration-resistant prostate cancer (CRPC). Since 2010, four new molecules with a demonstrated benefit (sipuleucel-T, cabazitaxel, abiraterone, and denosumab) have been approved in this setting, and to-date several other agents are under investigation in clinical trials. The purpose(More)
ated with hypoxia, edema, or other unknown processes. However, the patient had no history of hypotensive episodes, hypoxemia, abnormal metabolic and toxic processes, and other infectious disease. In conclusion, IAAE with pandemic (H1N1) 2009 may be caused by direct viral infection of the CNS and, although its pathogenesis is not clear, physicians should(More)
—A coded modulation scheme for the Poisson channel is investigated. The scheme relies on the serial concatenation of an outer low-density parity-check (LDPC) code over an order-q finite field and q-ary pulse position modulation (PPM). Due to the matching between code and modulation symbols, no iterative message exchange between the decoder and the modulator(More)
Arundo donax (giant reed) hydrolysate was exploited as a substrate for anaerobic digestion aimed to the production of biogas and biohydrogen. A mixed culture adapted from a primary sludge digester was used as inoculum. Besides the biogas, the anaerobic fermentation products were ethanol, acetic acid and butyric acid. Together, the soluble products accounted(More)
Propylene glycol (PG) is a main component of aircraft deicing fluids and its extensive use in Northern airports is a source of soil and groundwater contamination. Bacterial consortia able to grow on PG as sole carbon and energy source were selected from soil samples taken along the runways of Oslo Airport Gardermoen site (Norway). DGGE analysis of(More)
Unilateral cerebrovascular lesions occurring during adulthood have been reported to be accompanied by high-amplitude somatosensory evoked potentials over the nonaffected hemisphere; however, the mechanisms by which somatosensory evoked potential amplitude increases over the nonaffected hemisphere are still unclear. To investigate the eventual presence of(More)