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  • Raffaele Serra, Luca Gallelli, +12 authors Stefano de Franciscis
  • Medicine
  • Drug design, development and therapy
  • 2014 (First Publication: 13 May 2014)
  • Background Mixed venous and arterial ulcers account for approximately 15%–30% of all venous leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs) and neutrophilExpand
  • Shailendra R. Singh, Nikol Sullo, +16 authors D G Lambert
  • Medicine
  • British journal of pharmacology
  • 2016 (First Publication: 6 March 2016)
  • BACKGROUND AND PURPOSE There is evidence supporting a role for the nociceptin/orphanin FQ (N/OFQ; NOP) receptor and its endogenous ligand N/OFQ in the modulation of neurogenic inflammation, airwayExpand
  • Fiorentina Roviezzo, Antonio Carlo Bertolino, +9 authors Giuseppe Antonio Cirino
  • Medicine, Chemistry
  • Pharmacological research
  • 2015 (First Publication: 1 October 2015)
  • Compelling evidence suggests that hydrogen sulfide represents an important gaseous transmitter in the mammalian respiratory system. In the present study, we have evaluated the role of mast cells inExpand
  • Nikol Sullo, Fiorentina Roviezzo, +8 authors Bruno D'Agostino
  • Medicine, Chemistry
  • American journal of physiology. Lung cellular and…
  • 2013 (First Publication: 15 May 2013)
  • Several studies suggest that the N/OFQ (nociceptin/orphanin FQ)-NOP (N/OFQ peptide) receptor pathway is involved in airway physiology. We previously demonstrated a modulation of the endogenous N/OFQExpand
  • Anja M. Schaible, Rosanna Filosa, +18 authors Oliver Werz
  • Medicine, Chemistry
  • Biochemical pharmacology
  • 2016 (First Publication: 15 July 2016)
  • 5-Lipoxygenase (5-LO) catalyzes the first two steps in leukotriene (LT) biosynthesis. Because LTs play pivotal roles in allergy and inflammation, 5-LO represents a valuable target forExpand